4-(CHLOROMETHYL)-2-METHYLPYRIDINE

Product Name: 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
CAS No.: 75523-42-1
Chemical Name: 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
Synonyms: 4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(CHLOROMETHYL)-2-METHYLPYRIDINE;pyridine, 4-(chloroMethyl)-2-Methyl-;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;2-Methyl-4-(chloromethyl)pyridine (HCl)
CBNumber: CB22454432
Molecular Formula: C7H8ClN
Formula Weight: 141.6
MOL File: 75523-42-1.mol

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4-(CHLOROMETHYL)-2-METHYLPYRIDINE Property

Boiling point:: 218℃
Density: 1.118
Flash point:: 106℃

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C369655
Product name: 4-Chloromethyl-2-methylpyridine
Packaging: 5g
Price: $1320
Updated: 2021/12/16

AccelPharmtech

Product number: D2223
Product name: 4-(chloromethyl)-2-methyl-Pyridine
Purity: 97.00%
Packaging: 1G
Price: $2100
Updated: 2021/12/16

AccelPharmtech

Product number: D2223
Product name: 4-(chloromethyl)-2-methyl-Pyridine
Purity: 97.00%
Packaging: 5G
Price: $3590
Updated: 2021/12/16

AccelPharmtech

Product number: D2223
Product name: 4-(chloromethyl)-2-methyl-Pyridine
Purity: 97.00%
Packaging: 25G
Price: $6710
Updated: 2021/12/16

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4-(CHLOROMETHYL)-2-METHYLPYRIDINE Chemical Properties,Usage,Production

Uses

4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.

Synthesis

4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).

4-(CHLOROMETHYL)-2-METHYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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75523-42-1, 4-(CHLOROMETHYL)-2-METHYLPYRIDINERelated Search:

2-CHLORO-6-METHYLPYRIDINE-4-CARBONYL CHLORIDE 4-(CHLOROMETHYL)-2-METHYLPYRIDINE 4-QUINOLINECARBONYL CHLORIDE,6-CHLORO-2-PHENYL- Quinoline, 4-(chloromethyl)-2-methyl- (9CI) 2-Phenylquinoline-4-carboxylicacidchloride 6-bromo-2-phenylquinoline-4-carbonyl chloride 4-(CHLOROMETHYL)PYRIDINE-2-CARBONITRILE ETHYL 4-(CHLOROMETHYL)PYRIDINE-2-CARBOXYLATE 4-(CHLOROMETHYL)-2-PHENYLPYRIDINE 4-DICHLOROMETHYL-6-METHYL-2-PHENYL-QUINOLINE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-[4-(TRIFLUOROMETHYL)PHENYL]NICOTINONITRILE 4-DICHLOROMETHYL-2-PHENYL-QUINOLINE 4-(CHLOROMETHYL)-2-(3,4,5-TRIMETHOXYPHENYL)PYRIDINE 4-(CHLOROMETHYL)-2-(4-FLUOROPHENYL)PYRIDINE 2-PHENYL-QUINOLINE-4-CARBONYL CHLORIDE HYDROCHLORIDE 4-[CHLORO(DIFLUORO)METHYL]-2-HYDROXY-6-METHYLNICOTINONITRILE 2,4-BIS(TRICHLOROMETHYL)-7-CHLOROQUINOLINE 2,4-BIS(TRICHLOROMETHYL)QUINOLINE

4-(CHLOROMETHYL)-2-METHYLPYRIDINE

pyridine, 4-(chloroMethyl)-2-Methyl-

4-(Chloromethyl)-2-picoline

2-Methyl-4-(chloromethyl)pyridine

2-methyl-pyridin-4-ylmethyl chloride

4-Chloromethyl-2-methyl-pyridine.HCL

2-Methyl-4-(chloromethyl)pyridine (HCl)

75523-42-1

Aromatics, Heterocycles, Miscellaneous Reagents