ChemicalBook > CAS DataBase List > [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

Product Name: [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.: 850363-42-7
Chemical Name: [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
Synonyms: FPT18R078-TM2(Boc);N-Boc-1-(4-bromophenyl)ethanamine;N-Boc-4-bromo-alpha-methylbenzylamine;tert-butyl 1-(4-bromophenyl)ethylcarbamate;tert-Butyl N-[1-(4-broMophenyl)ethyl]carbaMate;[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, [1-(4-bromophenyl)ethyl]-, 1,1-dimethylethyl ester;Carbamic acid, N-[1-(4-bromophenyl)ethyl]-, 1,1-dimethylethyl ester
CBNumber: CB22460831
Molecular Formula: C13H18BrNO2
Formula Weight: 300.19
MOL File: 850363-42-7.mol

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[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER Property

Boiling point:: 383.1±25.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.94±0.46(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

TRC

Product number: B701303
Product name: [1-(4-Bromo-phenyl)-ethyl]-carbamicAcidtert-ButylEster
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B701303
Product name: [1-(4-Bromo-phenyl)-ethyl]-carbamicAcidtert-ButylEster
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: V8006
Product name: tert-ButylN-[1-(4-bromophenyl)ethyl]carbamate
Packaging: 250mg
Price: $88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0068950
Product name: (1-(4-BROMO-PHENYL)-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
Purity: 96.00%
Packaging: 5MG
Price: $502.01
Updated: 2021/12/16

J&W Pharmlab

Product number: 20R0553
Product name: [1-(4-Bromo-phenyl)-ethyl]-carbamicacidtert-butylester
Purity: 96%
Packaging: 1g
Price: $65
Updated: 2021/12/16

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[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

24424-99-5

24358-62-1

850363-42-7

General procedure for the synthesis of tert-butyl (1-(4-bromophenyl)ethyl)carbamate from di-tert-butyl dicarbonate and 1-(4-bromophenyl)ethylamine (refer to Example 5): synthesis of 1-bromo-4-(1-tert-butoxycarbonylaminoethyl)benzene (refer to compound 5). Triethylamine (2.09 mL) was added to a solution of 2.00 g (10.0 mmol) of 1-(4-bromophenyl)ethylamine in 22.3 mL of dichloromethane and the mixture was cooled in an ice bath. Under argon protection and stirring, 2.87 mL (12.0 mmol) of di-tert-butyl dicarbonate was slowly added to the mixture. Subsequently, the reaction mixture was warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction solution was poured into 200 mL of water and extracted with 200 mL of chloroform. The organic layer was washed sequentially with water, saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and concentrated under vacuum. The resulting solid was washed twice with 10 mL of hexane to give 2.71 g of tert-butyl (1-(4-bromophenyl)ethyl)carbamate as a white powder (yield: 90%). rf value: 0.55 (n-hexane: ethyl acetate=4:1, v/v). Mass spectrum (FAB, m/z): 300, 302 (M++1). 1H-NMR spectrum (DMSO-d6, δ ppm): 1.27 (d, J=6.8 Hz, 3H), 1.36 (brs, 9H), 4.51-4.64 (m, 1H), 7.25 (d, J=8.3 Hz, 2H), 7.35-7.45 (m, 1H) , 7.49 (d, J=8.3 Hz, 2H).

References

[1] Patent: EP1679308, 2006, A1. Location in patent: Page/Page column 32-33
[2] Patent: WO2010/97410, 2010, A1. Location in patent: Page/Page column 125
[3] Patent: US2012/40942, 2012, A1. Location in patent: Page/Page column 58
[4] Angewandte Chemie - International Edition, 2008, vol. 47, # 7, p. 1287 - 1290
[5] Patent: WO2013/40790, 2013, A1. Location in patent: Page/Page column 40

[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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850363-42-7, [1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTERRelated Search:

S-2-N-BOC-propane-1,2-diamine-HCl (S)-[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER R-1-N-CBZ-propane-1,2-diamine-HCl (R)-1-AMinopropan-2-ylcarbaMic Acid tert-Buty Ester benzyl 2-aMinopropylcarbaMate (R)-benzyl 2-aMinopropylcarbaMate Carbamic acid, [(1S)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) 1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester, (3S,5S)- Carbamic acid, (2-amino-1-methylethyl)-, 1,1-dimethylethyl ester (9CI) (R)-tert-butyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-N-BOC-propane-1,2-diamine-HCl (R)-[1-(4-Bromophenyl)ethyl]carbamic acid tert-butyl ester 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester (3R,5R)-1-Boc-3,5-diMethylpiperazine S-1-N-CBZ-propane-1,2-diamine-HCl S-2-N-BOC-propane-1,2-diamine hydrochloride Benzeneacetic acid,4-nitro-, 1,1-dimethylethyl ester CARBAMIC ACID, (3-BROMO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER

[1-(4-BROMO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER

tert-Butyl N-[1-(4-broMophenyl)ethyl]carbaMate

tert-butyl 1-(4-bromophenyl)ethylcarbamate

Carbamic acid, N-[1-(4-bromophenyl)ethyl]-, 1,1-dimethylethyl ester

Carbamic acid, [1-(4-bromophenyl)ethyl]-, 1,1-dimethylethyl ester

N-Boc-1-(4-bromophenyl)ethanamine

N-Boc-4-bromo-alpha-methylbenzylamine

FPT18R078-TM2(Boc)

850363-42-7