2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE
- Product Name
- 2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE
- CAS No.
- 5466-43-3
- Chemical Name
- 2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE
- Synonyms
- EOS-60937;4-dichloro-6;7-dihydro-5H-cyclopenta[d]pyriMidine;2,4-Dichloro-5,6-trimethylenepyrimidine;2,4-Dichloro-5H,6H,7H-cyclopenta[d]pyrimidine;2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE;5H-Cyclopentapyrimidine, 2,4-dichloro-6,7-dihydro-;2,4-dichloro-6,7-dihydro-1H-cyclopenta[d]pyrimidine;2,4-dichloro-6,7-dihydro-5H-cyclopenta[d][1,3]chlorazine;2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- CBNumber
- CB22460947
- Molecular Formula
- C7H6Cl2N2
- Formula Weight
- 189.04
- MOL File
- 5466-43-3.mol
2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE Property
- Melting point:
- 70-72℃
- Boiling point:
- 307℃
- Density
- 1.466
- Flash point:
- 168℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.78±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChIKey
- GDHHAOFBLGZCMI-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 762296
- Product name
- 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $98.03
- Updated
- 2025/07/31
- Product number
- D438133
- Product name
- 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD32826
- Product name
- 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-W008301
- Product name
- 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- Purity
- 99.87%
- Packaging
- 5g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- FD32826
- Product name
- 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
- Packaging
- 1g
- Price
- $157.5
- Updated
- 2021/12/16
2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE Chemical Properties,Usage,Production
Synthesis
5466-00-2
5466-43-3
General procedure for the synthesis of 2,4-dichloro-5,6-trimethylpyrimidine from 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione: 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione (0.3 g, 1.97 mmol) was suspended in phosphorochloridic acid (5 ml) and heated to reflux overnight. Upon completion of the reaction, the reaction mixture was cooled to room temperature followed by slow addition of water under ice bath conditions. The precipitated product was collected by filtration and dried to give 2,4-dichloro-5,6-trimethylpyrimidine as a yellow solid. Yield: 92%. 1H NMR (DMSO-d6, 300 MHz): δ 3.13 (t, 2H, cyclopentyl-CH2), 3.00 (t, 2H, cyclopentyl-CH2), 2.23 (m, 2H, cyclopentyl-CH2).
References
[1] European Journal of Medicinal Chemistry, 1980, vol. 15, # 4, p. 317 - 322
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 246 - 256
[3] Patent: US2010/144731, 2010, A1. Location in patent: Page/Page column 22
[4] Patent: US2007/281949, 2007, A1. Location in patent: Page/Page column 93-94
[5] Patent: US2014/179668, 2014, A1. Location in patent: Paragraph 0829
2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE Suppliers
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View Lastest Price from 2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE manufacturers
- Product
- 2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE 5466-43-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 2,4-DICHLORO-6,7-DIHYDRO-5H-CYCLOPENTAPYRIMIDINE 5466-43-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25