5-Chloropyrazine-2-carboxylic acid hydrazide
- Product Name
- 5-Chloropyrazine-2-carboxylic acid hydrazide
- CAS No.
- 848952-83-0
- Chemical Name
- 5-Chloropyrazine-2-carboxylic acid hydrazide
- Synonyms
- 5-chloropyrazine-2-carbohydrazide;5-Chloropyrazine-2-carboxylic acid hydrazide;5-chloropyrazine-2-carboxylic acid hydyazide;2-Pyrazinecarboxylic acid, 5-chloro-, hydrazide
- CBNumber
- CB22470157
- Molecular Formula
- C5H5ClN4O
- Formula Weight
- 172.57
- MOL File
- 848952-83-0.mol
5-Chloropyrazine-2-carboxylic acid hydrazide Property
- Density
- 1.496±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.51±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381238
- Product name
- 5-Chloropyrazine-2-carboxylicacidhydrazide
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C381238
- Product name
- 5-Chloropyrazine-2-carboxylicacidhydrazide
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC144192
- Product name
- 5-Chloropyrazine-2-carboxylic acid hydrazide
- Packaging
- 100mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 073308
- Product name
- 5-Chloropyrazine-2-carboxylic acid hydrazide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $899
- Updated
- 2021/12/16
- Product number
- W8760
- Product name
- 5-Chloropyrazine-2-carboxylicacidhydrazide
- Packaging
- 5g
- Price
- $957
- Updated
- 2021/12/16
5-Chloropyrazine-2-carboxylic acid hydrazide Chemical Properties,Usage,Production
Synthesis
33332-25-1
848952-83-0
General procedure for the synthesis of 5-chloropyrazine-2-carboxylic acid hydrazide from methyl 5-chloropyrazine-2-carboxylate: 1. Preparation of 5-chloropyrazine-2-carboxylic acid hydrazide: 5-chloropyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL). The reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the mixture was filtered, the precipitate was collected and dried under vacuum to afford the target product 5-chloropyrazine-2-carboxylic acid hydrazine in a yield of 5.01 g (50% yield). Product characterization data: 1H NMR (CDCl3, 400 MHz) δ: 4.09 (d, 2H), 8.52 (s, 1H), 8.66 (bs, 1H), 9.14 (s, 1H). Elemental analysis: C5H5ClN4O Theoretical values: C 34.80; H 2.92; N 32.47; Measured values: C 34.89; H 2.91; N 32.32. Mass spectral data: MS APCI+ m/z 173 [MH]+.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 13, p. 5344 - 5354
[2] Patent: WO2007/17752, 2007, A1. Location in patent: Page/Page column 33
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 10, p. 2634 - 2636
[4] Patent: WO2006/100557, 2006, A1. Location in patent: Page/Page column 24
5-Chloropyrazine-2-carboxylic acid hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloropyrazine-2-carboxylic acid hydrazide Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 021-24206007 13764915196
- Fax
- 86-021-23027023
- sales@balmxy.com
- Country
- China
- ProdList
- 6874
- Advantage
- 55
- Tel
- 028-64353063
- Fax
- 028-64353063 QQ:784253935
- reacchemical@163.com
- Country
- China
- ProdList
- 5253
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58