1-Boc-4-chloro-3-formylindole
- Product Name
- 1-Boc-4-chloro-3-formylindole
- CAS No.
- 914349-00-1
- Chemical Name
- 1-Boc-4-chloro-3-formylindole
- Synonyms
- 1-Boc-4-chloro-3-formylindole;4-Chloro-3-formyl-1H-indole, N-BOC protected;4-Chloro-3-formyl-1H-indole,N-BOCprotected98%;tert-butyl 4-chloro-3-formylindole-1-carboxylate;4-Chloro-3-formyl-1H-indole, N-BOC protected 98%;tert-Butyl 4-chloro-3-forMyl-1H-indole-1-carboxylate;1H-INDOLE-1-CARBOXYLIC ACID, 4-CHLORO-3-FORMYL-, 1,1-DIMETHYLETHYL ESTER;tert-Butyl 4-chloro-3-formyl-1H-indole-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-chloro-1H-indole-3-carboxaldehyde
- CBNumber
- CB22471073
- Molecular Formula
- C14H14ClNO3
- Formula Weight
- 279.72
- MOL File
- 914349-00-1.mol
1-Boc-4-chloro-3-formylindole Property
- Boiling point:
- 409.4±48.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B807093
- Product name
- tert-Butyl4-Chloro-3-formyl-1H-indole-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB154007
- Product name
- 1-Boc-4-Chloro-3-formylindole
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB154007
- Product name
- 1-Boc-4-Chloro-3-formylindole
- Packaging
- 2g
- Price
- $191
- Updated
- 2021/12/16
- Product number
- FB154007
- Product name
- 1-Boc-4-Chloro-3-formylindole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 4H56-5-Q5
- Product name
- 4-Chloroindole-3-carboxaldehyde, N-Boc protected
- Purity
- 98%
- Packaging
- 1g
- Price
- $68
- Updated
- 2021/12/16
1-Boc-4-chloro-3-formylindole Chemical Properties,Usage,Production
Synthesis
876-72-2
24424-99-5
914349-00-1
General procedure for the synthesis of 1-Boc-4-chloro-3-formylindole from 4-chloroindole-3-carboxaldehyde and di-tert-butyl dicarbonate: To a solution of 4-chloroindole-3-carboxaldehyde (1.0 eq.) and di-tert-butyl dicarbonate (1.2 eq.) in acetonitrile was added DMAP (0.1 eq.). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in dichloromethane and washed with saturated sodium bicarbonate solution. The organic and aqueous phases were separated. The aqueous phase was extracted with dichloromethane. All organic phases were combined and washed sequentially with saturated ammonium chloride solution, water and brine. The organic phase was dried with magnesium sulfate, filtered and concentrated under reduced pressure. The resulting BOC-protected 1-Boc-4-chloro-3-formylindole can be used in the next step without further purification.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9179 - 9195
[2] Patent: WO2013/45516, 2013, A1. Location in patent: Page/Page column 129; 151
1-Boc-4-chloro-3-formylindole Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-4-chloro-3-formylindole Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 1-Boc-4-chloro-3-formylindole manufacturers
- Product
- 1-Boc-4-chloro-3-formylindole 914349-00-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-28