4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 492431-11-5
- Chemical Name
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- Zinc02563759;1-Boc-4-(6-Chloropyridazin-3-yl);1-Boc-4-(6-chloro-3-pyridazinyl)piperazine;1-Boc-4-(6-chloropyridazin-3-yl)piperazine;1-N-Boc-4-(6-chloropyridazin-3-yl)piperazine;4-(6-Chloropyridazin-3-yl)piperazine, N1-BOC protected;tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid t-Butyl Ester;4-(6-chloro-3-pyridazinyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicacidtert-butylester95%
- CBNumber
- CB4326962
- Molecular Formula
- C13H19ClN4O2
- Formula Weight
- 298.77
- MOL File
- 492431-11-5.mol
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light brown to off-white Solid
Safety
- Hazard Codes
- Xi
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C351005
- Product name
- 4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicAcidtert-ButylEster
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB139516
- Product name
- tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate
- Packaging
- 2g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FB139516
- Product name
- tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate
- Packaging
- 5G
- Price
- $162
- Updated
- 2021/12/16
- Product number
- B121
- Product name
- 4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylicacidtert-butylester
- Packaging
- 10g
- Price
- $164
- Updated
- 2021/12/16
- Product number
- 071771
- Product name
- 1-Boc-4-(6-Chloropyridazin-3-yl)piperazine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $215
- Updated
- 2021/12/16
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid tert-Butyl Ester
Synthesis
141-30-0
57260-71-6
492431-11-5
To 3,6-dichloropyridazine (57.3 g, 385 mmol) and N-BOC-piperazine (71.6 g, 358 mmol) in 1,4-dioxane (250 mL) was added N,N-diisopropylethylamine (66.9 mL, 385 mmol). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (3 L) and washed sequentially with 10% citric acid solution, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from ethyl acetate to give tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate as an off-white solid (101 g, 88% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ESI): 1H NMR δ 1.25 (9H, s), 3.26-3.47 (8H, m), 6.67 (1H, d, J = 9.6 Hz), 7.00 (1H, d, J = 9.6 Hz); MS (ESI) m/z: 299.0 [M + H]+.
References
[1] Patent: US2015/353542, 2015, A1. Location in patent: Paragraph 0539
[2] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: WO2017/197051, 2017, A1. Location in patent: Page/Page column 299
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379
[5] Patent: US2005/176722, 2005, A1. Location in patent: Page/Page column 19
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 021-34979681; 17701870669
- Fax
- 021-34979681
- 41513101@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 55
- Tel
- 00000000000
- Fax
- -
- sales@qingcangchem.com
- Country
- China
- ProdList
- 509
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
View Lastest Price from 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 492431-11-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 492431-11-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- KG/T
- Release date
- 2019-12-19