ChemicalBook > CAS DataBase List > 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.
492431-11-5
Chemical Name
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms
Zinc02563759;1-Boc-4-(6-Chloropyridazin-3-yl);1-Boc-4-(6-chloro-3-pyridazinyl)piperazine;1-Boc-4-(6-chloropyridazin-3-yl)piperazine;1-N-Boc-4-(6-chloropyridazin-3-yl)piperazine;4-(6-Chloropyridazin-3-yl)piperazine, N1-BOC protected;tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid t-Butyl Ester;4-(6-chloro-3-pyridazinyl)-1-piperazinecarboxylic acid tert-butyl ester;4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicacidtert-butylester95%
CBNumber
CB4326962
Molecular Formula
C13H19ClN4O2
Formula Weight
298.77
MOL File
492431-11-5.mol
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4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Appearance
Light brown to off-white Solid
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Safety

Hazard Codes 
Xi
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C351005
Product name
4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicAcidtert-ButylEster
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139516
Product name
tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate
Packaging
2g
Price
$81
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139516
Product name
tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate
Packaging
5G
Price
$162
Updated
2021/12/16
AK Scientific
Product number
B121
Product name
4-(6-Chloro-pyridazin-3-yl)-piperazine-1-carboxylicacidtert-butylester
Packaging
10g
Price
$164
Updated
2021/12/16
Matrix Scientific
Product number
071771
Product name
1-Boc-4-(6-Chloropyridazin-3-yl)piperazine
Purity
95+%
Packaging
5g
Price
$215
Updated
2021/12/16
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4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid tert-Butyl Ester

Synthesis

141-30-0

57260-71-6

492431-11-5

To 3,6-dichloropyridazine (57.3 g, 385 mmol) and N-BOC-piperazine (71.6 g, 358 mmol) in 1,4-dioxane (250 mL) was added N,N-diisopropylethylamine (66.9 mL, 385 mmol). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (3 L) and washed sequentially with 10% citric acid solution, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by recrystallization from ethyl acetate to give tert-butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate as an off-white solid (101 g, 88% yield). The product was confirmed by 1H NMR (400 MHz, CDCl3) and mass spectrometry (ESI): 1H NMR δ 1.25 (9H, s), 3.26-3.47 (8H, m), 6.67 (1H, d, J = 9.6 Hz), 7.00 (1H, d, J = 9.6 Hz); MS (ESI) m/z: 299.0 [M + H]+.

References

[1] Patent: US2015/353542, 2015, A1. Location in patent: Paragraph 0539
[2] Patent: EP3305785, 2018, A1. Location in patent: Paragraph 0204; 0205
[3] Patent: WO2017/197051, 2017, A1. Location in patent: Page/Page column 299
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379
[5] Patent: US2005/176722, 2005, A1. Location in patent: Page/Page column 19

4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

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View Lastest Price from 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Dideu Industries Group Limited
Product
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 492431-11-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02
Career Henan Chemical Co
Product
4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 492431-11-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-19

492431-11-5, 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE 1-Boc-5-formylindoline 7-Bromo-1H-indole, N-BOC protected 1-(5-Bromo-3-pyridyl)-4-tert-butoxycarbonylpiperazine TERT-BUTYL 4-[2-(AMINOMETHYL)PHENYL]PIPERAZINE-1-CARBOXYLATE 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine 4-[(AMINOIMINOMETHYL)AMINO]-1-PIPERIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER MONOHYDROCHLORIDE 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate 1-Boc-4-chloro-3-formylindole TERT-BUTYL 5-METHYLSPIRO[INDOLINE-3,4'-PIPERIDINE]-1-CARBOXYLATE 1-BOC-6-CHLOROINDOLE TERT-BUTYL 6-BROMO-1H-INDOLE-1-CARBOXYLATE 1-(6-Pyridazinyl)piperazine 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-CHLORO-6-(4-METHYL-1-PIPERAZINYL)PYRIDAZINE tert-Butyl 1-piperazinecarboxylate 1-(6-Chloropyridazino-3-yl)piperazine

  • 1-Boc-4-(6-chloropyridazin-3-yl)piperazine
  • 4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylic Acid t-Butyl Ester
  • Zinc02563759
  • 1-N-Boc-4-(6-chloropyridazin-3-yl)piperazine
  • tert-Butyl 4-(6-chloropyridazin-3-yl)piperazine-1-carboxylate
  • 4-(6-chloro-3-pyridazinyl)-1-piperazinecarboxylic acid tert-butyl ester
  • 1-Boc-4-(6-chloro-3-pyridazinyl)piperazine
  • 1-Boc-4-(6-Chloropyridazin-3-yl)
  • 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-(6-Chloropyridazin-3-yl)piperazine, N1-BOC protected
  • 4-(6-CHLOROPYRIDAZIN-3-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95%
  • 4-(6-Chloropyridazin-3-yl)piperazine-1-carboxylicacidtert-butylester95%
  • 1-Piperazinecarboxylic acid, 4-(6-chloro-3-pyridazinyl)-, 1,1-dimethylethyl ester
  • 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH
  • 492431-11-5
  • C13H19ClN4O2