1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Product Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
CAS No.: 280110-69-2
Chemical Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
Synonyms: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl);Benzoicacid,8-(chlorosulfonyl)-,methylester;1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine;tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester
CBNumber: CB42549851
Molecular Formula: C13H21N3O3
Formula Weight: 267.32
MOL File: 280110-69-2.mol

More

Less

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Property

Melting point:: 69 °C
Boiling point:: 384.0±52.0 °C(Predicted)
Density: 1.140±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -2.58±0.40(Predicted)
Appearance: Off-white to light yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 100mg
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 250mg
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 50mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 500mg
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: W5094
Product name: 1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine
Packaging: 1g
Price: $517
Updated: 2021/12/16

More

Less

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Chemical Properties,Usage,Production

Synthesis

4637-24-5

187834-88-4

280110-69-2

To a solution of 9.0 g 1-BOC-4-piperidinecarbohydrazide (37 mmol, 1 eq.) in 40 mL of THF was added 8.1 mL of N,N-dimethylformamide dimethyl acetal (55.4 mmol, 1.5 eq.). The reaction mixture was stirred under nitrogen protection at 50 °C for 4 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in 40 mL of toluene and 400 mg of p-toluenesulfonic acid was added. The mixture was heated at 100 °C and protected by nitrogen for 18 hours. At the end of the reaction, the volatiles were removed under reduced pressure and the residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The organic phase was dried with magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent dichloromethane/methanol (98:2 v/v to 95:5 v/v) to afford 8.07 g of 1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine as a white solid in 81% yield.1H NMR (400 MHz, CD3OD): δ 1.42 (s, 9H), 1.70 (m , 2H), 2.05 (m, 2H), 2.50 (s, 3H), 3.00 (m, 2H), 3.15 (m, 1H), 4.05 (m, 2H); LCMS: m/z APCl+, 268 [MH]+; Elemental analysis results: C, 58.26%; H, 7.96%; N, 15.78%; theoretical value (C13H21N3O3 ): C, 58.41%; H, 7.92%; N, 15.72%.

References

[1] Patent: US2005/154024, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 46-47

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Suppliers

China 28 Germany 1 India 1 United Kingdom 1 United States 6 Global 37

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Zhengzhou Guancheng Laboratory equipment Sales

Tel: 0371-88888888 272369594
Fax: QQ:272369594
Email: 2723695949@qq.com
Country: China
ProdList: 4981
Advantage: 50

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Aikon International Limited

Tel: 025-66061636 19370895928
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15813
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4968
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 24972
Advantage: 58

280110-69-2, 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidineRelated Search:

1-tert-Butyl 3-Methyl 4-aMino-1H-pyrazole-1,3-dicarboxylate ETHYL 1-BOC-5-OXO-HEXAHYDRO-1H-AZEPINE-4-CARBOXYLATE 1-Boc-5-formylindoline 7-Bromo-1H-indole, N-BOC protected 1-(5-Bromo-3-pyridyl)-4-tert-butoxycarbonylpiperazine TERT-BUTYL 4-[2-(AMINOMETHYL)PHENYL]PIPERAZINE-1-CARBOXYLATE 4-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-[(AMINOIMINOMETHYL)AMINO]-1-PIPERIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER MONOHYDROCHLORIDE 1-BOC-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate 1-Boc-4-chloro-3-formylindole TERT-BUTYL 5-METHYLSPIRO[INDOLINE-3,4'-PIPERIDINE]-1-CARBOXYLATE 1-BOC-6-CHLOROINDOLE TERT-BUTYL 6-BROMO-1H-INDOLE-1-CARBOXYLATE

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)

1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester

Benzoicacid,8-(chlorosulfonyl)-,methylester

280110-69-2