ChemicalBook > CAS DataBase List > 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Product Name
1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
CAS No.
280110-69-2
Chemical Name
1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
Synonyms
1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl);Benzoicacid,8-(chlorosulfonyl)-,methylester;1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine;tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester
CBNumber
CB42549851
Molecular Formula
C13H21N3O3
Formula Weight
267.32
MOL File
280110-69-2.mol
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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Property

Melting point:
69 °C
Boiling point:
384.0±52.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-2.58±0.40(Predicted)
Appearance
Off-white to light yellow Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB141951
Product name
tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging
100mg
Price
$98
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141951
Product name
tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging
250mg
Price
$195
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141951
Product name
tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging
50mg
Price
$56
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB141951
Product name
tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging
500mg
Price
$340
Updated
2021/12/16
AK Scientific
Product number
W5094
Product name
1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine
Packaging
1g
Price
$517
Updated
2021/12/16
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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Chemical Properties,Usage,Production

Synthesis

4637-24-5

187834-88-4

280110-69-2

To a solution of 9.0 g 1-BOC-4-piperidinecarbohydrazide (37 mmol, 1 eq.) in 40 mL of THF was added 8.1 mL of N,N-dimethylformamide dimethyl acetal (55.4 mmol, 1.5 eq.). The reaction mixture was stirred under nitrogen protection at 50 °C for 4 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in 40 mL of toluene and 400 mg of p-toluenesulfonic acid was added. The mixture was heated at 100 °C and protected by nitrogen for 18 hours. At the end of the reaction, the volatiles were removed under reduced pressure and the residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The organic phase was dried with magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent dichloromethane/methanol (98:2 v/v to 95:5 v/v) to afford 8.07 g of 1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine as a white solid in 81% yield.1H NMR (400 MHz, CD3OD): δ 1.42 (s, 9H), 1.70 (m , 2H), 2.05 (m, 2H), 2.50 (s, 3H), 3.00 (m, 2H), 3.15 (m, 1H), 4.05 (m, 2H); LCMS: m/z APCl+, 268 [MH]+; Elemental analysis results: C, 58.26%; H, 7.96%; N, 15.78%; theoretical value (C13H21N3O3 ): C, 58.41%; H, 7.92%; N, 15.72%.

References

[1] Patent: US2005/154024, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 46-47

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Suppliers

China 27 Germany 1 India 1 United Kingdom 1 United States 6 Global 36
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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NovoChemy Ltd.
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021-31261262/ 49 (0)17662837245
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Shanghai Topbiochem Technology Co., Ltd
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+86-21-60341587
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+86-21-61294319
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SynAsst Chemical.
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Hangzhou Molcore Biopharmatech Co.,Ltd
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Aikon International Limited
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Suzhou Nuoouman Biological Technology Co., Ltd.
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15026866316
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Shanghai Haohong Pharmaceutical Co., Ltd.
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Shanghai ZiHao Pharmaceutical Co., Ltd.
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280110-69-2, 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidineRelated Search:

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  • 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
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  • 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)
  • 1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester
  • Benzoicacid,8-(chlorosulfonyl)-,methylester
  • 280110-69-2