1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

Product Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
CAS No.: 280110-69-2
Chemical Name: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine
Synonyms: 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl);Benzoicacid,8-(chlorosulfonyl)-,methylester;1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine;tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester
CBNumber: CB42549851
Molecular Formula: C13H21N3O3
Formula Weight: 267.32
MOL File: 280110-69-2.mol

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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Property

Melting point:: 69 °C
Boiling point:: 384.0±52.0 °C(Predicted)
Density: 1.140±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -2.58±0.40(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 100mg
Price: $98
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 250mg
Price: $195
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 50mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141951
Product name: tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate
Packaging: 500mg
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: W5094
Product name: 1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine
Packaging: 1g
Price: $517
Updated: 2021/12/16

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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Chemical Properties,Usage,Production

Synthesis

4637-24-5

187834-88-4

280110-69-2

To a solution of 9.0 g 1-BOC-4-piperidinecarbohydrazide (37 mmol, 1 eq.) in 40 mL of THF was added 8.1 mL of N,N-dimethylformamide dimethyl acetal (55.4 mmol, 1.5 eq.). The reaction mixture was stirred under nitrogen protection at 50 °C for 4 hours. After completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in 40 mL of toluene and 400 mg of p-toluenesulfonic acid was added. The mixture was heated at 100 °C and protected by nitrogen for 18 hours. At the end of the reaction, the volatiles were removed under reduced pressure and the residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The organic phase was dried with magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent dichloromethane/methanol (98:2 v/v to 95:5 v/v) to afford 8.07 g of 1-Boc-4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine as a white solid in 81% yield.1H NMR (400 MHz, CD3OD): δ 1.42 (s, 9H), 1.70 (m , 2H), 2.05 (m, 2H), 2.50 (s, 3H), 3.00 (m, 2H), 3.15 (m, 1H), 4.05 (m, 2H); LCMS: m/z APCl+, 268 [MH]+; Elemental analysis results: C, 58.26%; H, 7.96%; N, 15.78%; theoretical value (C13H21N3O3 ): C, 58.41%; H, 7.92%; N, 15.72%.

References

[1] Patent: US2005/154024, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 46-47

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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280110-69-2, 1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidineRelated Search:

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1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidine

tert-Butyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate

1-Boc-4-(5-Methyl-1,3,4-oxadiazol-2-yl)

1-Piperidinecarboxylic acid, 4-(5-methyl-1,3,4-oxadiazol-2-yl)-, 1,1-dimethylethyl ester

Benzoicacid,8-(chlorosulfonyl)-,methylester

280110-69-2