Uses
ChemicalBook > CAS DataBase List > 1-Boc-3-(cyanomethylene)azetidine

1-Boc-3-(cyanomethylene)azetidine

Uses
Product Name
1-Boc-3-(cyanomethylene)azetidine
CAS No.
1153949-11-1
Chemical Name
1-Boc-3-(cyanomethylene)azetidine
Synonyms
tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate;benzyl 3-(cyanomethylene)azetidine-1-carboxylate;3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester;Baricitinib-013;Baricitinib Impurity 10;tert-Butyl 3-(cyanomethylene);1-Boc-3-(cyanomethylene)azetidine;P-Hydroxy phenyl butanone (Raspberry ketone);1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine;ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate
CBNumber
CB22485423
Molecular Formula
C10H14N2O2
Formula Weight
194.23
MOL File
1153949-11-1.mol
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1-Boc-3-(cyanomethylene)azetidine Property

Boiling point:
309.7±35.0 °C(Predicted)
Density 
1.215
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-1.88±0.20(Predicted)
color 
White to Orange to Green
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Safety

RIDADR 
UN 3439 6.1/PG III
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5217
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity
>95.0%(GC)
Packaging
200mg
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
B5217
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity
>95.0%(GC)
Packaging
1g
Price
$148
Updated
2024/03/01
TRC
Product number
B117850
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
B117850
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging
25g
Price
$340
Updated
2021/12/16
Apolloscientific
Product number
OR930876
Product name
tert-Butyl3-(cyanomethylene)azetidine-1-carboxylate
Purity
95%
Packaging
10g
Price
$135
Updated
2021/12/16
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1-Boc-3-(cyanomethylene)azetidine Chemical Properties,Usage,Production

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

1-Boc-3-(cyanomethylene)azetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-(cyanomethylene)azetidine Suppliers

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View Lastest Price from 1-Boc-3-(cyanomethylene)azetidine manufacturers

Nanjing Fred Technology Co., Ltd
Product
1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
R&D Scientific Inc.
Product
tert-butyl 3-(cyanomethylidene)azetidine-1-carboxylate 1153949-11-1
Price
US $880.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-04-05
Henan Fengda Chemical Co., Ltd
Product
1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price
US $500.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000 ton/year
Release date
2023-12-21

1153949-11-1, 1-Boc-3-(cyanomethylene)azetidineRelated Search:

3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 1-N-Boc-3-hydroxyazetidine (R)-1-Boc-2-cyanopyrrolidine tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-pyrroline tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate tert-Butyl 4-broMo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate Baricitinib tert-butyl 3-oxidanyl-3-pyridin-2-yl-azetidine-1-carboxylate tert-butyl 4-((4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)Methyl)piperazine-1-carboxylate 1-Boc-Azetidine-3-yl-methanol tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate tert-butyl 2,2,4,8-tetraMethyl-1,2,3,4-tetrahydroquinolin-7-ylcarbaMate tert-butyl 3-(4-(7-carbamoyl-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)aMino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate

  • 1-Boc-3-(cyanomethylene)azetidine
  • 3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester
  • tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate
  • tert-butyl 3-(cyanoMethylidene)azetidine-1-carboxylate
  • 3-(Cyanomethylene)-1-azetidinecarboxylic acid tert-butyl ester
  • 1-(<i>tert</i>-Butoxycarbonyl)-3-(cyanomethylene)azetidine
  • P-Hydroxy phenyl butanone (Raspberry ketone)
  • tert-Butyl 3-(cyanomethylene)
  • 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
  • 1-Azetidinecarboxylic acid, 3-(cyanomethylene)-, 1,1-dimethylethyl ester
  • Baricitinib Impurity 10
  • benzyl 3-(cyanomethylene)azetidine-1-carboxylate
  • Baricitinib-013
  • ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate
  • 1153949-11-1