tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

Uses Uses

Product Name: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
CAS No.: 877399-74-1
Chemical Name: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
Synonyms: 1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester;tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate;tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate;4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester;Crizotinib Impurity 2;Crizotinib Impurity 1;CrizotinibIntermediate4;Crizotinib intermediates 2;InterMediate Ⅱ of Crizotinib;Borate fragment of crizotinib
CBNumber: CB71504562
Molecular Formula: C19H32BN3O4
Formula Weight: 377.29
MOL File: 877399-74-1.mol

More

Less

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Property

Melting point:: 114.0 to 118.0 °C
Boiling point:: 492.8±35.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder to crystal
pka: 2.89±0.19(Predicted)
color: White to Almost white
InChI: InChI=1S/C19H32BN3O4/c1-17(2,3)25-16(24)22-10-8-15(9-11-22)23-13-14(12-21-23)20-26-18(4,5)19(6,7)27-20/h12-13,15H,8-11H2,1-7H3
InChIKey: QSQWENQPOSRWLP-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(N2C=C(B3OC(C)(C)C(C)(C)O3)C=N2)CC1

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B5002
Product name: tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $170
Updated: 2025/07/31

TCI Chemical

Product number: B5002
Product name: tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $509
Updated: 2025/07/31

TRC

Product number: B663855
Product name: 1-(1-Boc-4-piperidyl)pyrazole-4-boronicAcidPinacolEster
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32980
Product name: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
Packaging: 5G
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: X4864
Product name: 1-(1-Boc-4-piperidyl)pyrazole-4-boronicAcidPinacolEster
Packaging: 5g
Price: $52
Updated: 2021/12/16

More

Less

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is mainly used as a pharmaceutical intermediate.

Uses

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is an intermediate in organic synthesis and pharmaceutical research and development, and can be used in laboratory organic synthesis processes.

Synthesis

Synthesis of tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate from 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine and 1-4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane), which can also be obtained by purification and isolation from tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate.

or

References

[1] Patent: WO2014/193647, 2014, A2. Location in patent: Paragraph 0185
[2] Patent: CN104119331, 2018, B. Location in patent: Paragraph 0382; 0390; 0391
[3] Patent: WO2010/68292, 2010, A1. Location in patent: Page/Page column 85-86
[4] Patent: WO2014/89280, 2014, A1. Location in patent: Page/Page column 50
[5] Patent: CN103833753, 2017, B. Location in patent: Paragraph 0352; 0358; 0359

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Suppliers

Americas 1 China 317 Europe 1 India 4 Japan 1 United Kingdom 3 United States 16 Global 343

Hunan Eurasian Pharmaceutical Co. Ltd.

Tel: 0592-5789919 13328776692
Email: 2851802016@qq.com
Country: China
ProdList: 79
Advantage: 58

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 252
Advantage: 58

Jiangsu Tairuite Pharmaceutical Technology Co., Ltd

Tel: 15151368970
Email: sweetingyuanyuan@163.com
Country: China
ProdList: 31
Advantage: 58

LEADMEDPHARM CO.,LTD

Tel: 13674959855 13674959855
Email: sales@synthontech.com
Country: China
ProdList: 3035
Advantage: 58

Shandong Xindao Pharmaceutical Technology Co.,Ltd

Tel: 0546-5612566 18019700392
Email: 3625645361@qq.com
Country: China
ProdList: 44
Advantage: 58

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 603
Advantage: 58

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 239
Advantage: 61

More

Less

View Lastest Price from tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl] piperidine-1-carboxylate 877399-74-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-28

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate 877399-74-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ＞98% by HPLC
Supply Ability: 10kg/month
Release date: 2023-01-09

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate 877399-74-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

877399-74-1, tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylateRelated Search:

1,4-Dioxane Diethylene glycol monobutyl ether Cyhalofop-butyl Pyrazole Butyl acetate 2-Chloro-2-methylpropane Haloperidol Selenium dioxide Buprofezin tert-Butanol 2-Butoxyethanol Butyl acrylate tert-Butyl 4-broMo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (R)-1-Boc-2-cyanopyrrolidine 1-N-Boc-3-hydroxyazetidine 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 1-Boc-3-(cyanomethylene)azetidine

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

1-(4-N-Boc-piperidine)pyrazole-4-boronic acid pinacol ester

<i>tert</i>-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-car

Crizotinib intermediates 2

1-Piperidinecarboxylic acid, 4

Borate fragment of crizotinib

Crizotinib Impurity 2

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylatetert-Butyl

4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL) -1H-PYRAZOL-1-YL]PIPERIDINE-1-CARBOXYLATE_ 877399-74-1

1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid picol ester

1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester

1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester

4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl)piperidine-1-carb

tert-butyl 4-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H

1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]-, 196%

tert-Butyl 4-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxyla

5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine

4-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)PIPERIDINE-1-CARBOXYLATE

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carbox

1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid pinacol ester

tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate

tert-butyl 4-(3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrol-1-yl)piperidine-1-carboxylate

InterMediate Ⅱ of Crizotinib

tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate &gt

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-

4 - [4 - (4 - (4,4,5,5 31 - methyl - 1-2 oxygen mixed boron borane - 2 - base) - 1 h - pyrazole - 1 - base] piperidine - 1 - formic acid tert-butyl ester

2-[1-(1-Boc-piperidin-4-yl)pyrazol-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate ISO 9001：2015 REACH

Crizotinib Impurity 1

tert-butyl 4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate

1-(N-Boc-piperidine-4-ly)-boronicacid pinacol ester

CrizotinibIntermediate4

1-(N-Boc-piperidin-4-yl)-1H-pyrazole-4-boronic acid pinacol ester

tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate , Crizotinib Impurity 5

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylicacidtert-butylester

1-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate - [B10044]

877399-74-1

977399-74-1

977399-47-1

C19H32BN3O4