Uses Uses
ChemicalBook > CAS DataBase List > tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate

Uses Uses
Product Name
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
CAS No.
877399-74-1
Chemical Name
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
Synonyms
1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester;tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate;tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate;4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester;Crizotinib Impurity 2;Crizotinib Impurity 1;CrizotinibIntermediate4;Crizotinib intermediates 2;InterMediate Ⅱ of Crizotinib;Borate fragment of crizotinib
CBNumber
CB71504562
Molecular Formula
C19H32BN3O4
Formula Weight
377.29
MOL File
877399-74-1.mol
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tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Property

Melting point:
114.0 to 118.0 °C
Boiling point:
492.8±35.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
powder to crystal
pka
2.89±0.19(Predicted)
color 
White to Almost white
InChI
InChI=1S/C19H32BN3O4/c1-17(2,3)25-16(24)22-10-8-15(9-11-22)23-13-14(12-21-23)20-26-18(4,5)19(6,7)27-20/h12-13,15H,8-11H2,1-7H3
InChIKey
QSQWENQPOSRWLP-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(N2C=C(B3OC(C)(C)C(C)(C)O3)C=N2)CC1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5002
Product name
tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$170
Updated
2025/07/31
TCI Chemical
Product number
B5002
Product name
tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$509
Updated
2025/07/31
TRC
Product number
B663855
Product name
1-(1-Boc-4-piperidyl)pyrazole-4-boronicAcidPinacolEster
Packaging
1g
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB32980
Product name
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
Packaging
5G
Price
$50
Updated
2021/12/16
AK Scientific
Product number
X4864
Product name
1-(1-Boc-4-piperidyl)pyrazole-4-boronicAcidPinacolEster
Packaging
5g
Price
$52
Updated
2021/12/16
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tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Chemical Properties,Usage,Production

Uses

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is mainly used as a pharmaceutical intermediate.

Uses

4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxacyclopentaborane-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester is an intermediate in organic synthesis and pharmaceutical research and development, and can be used in laboratory organic synthesis processes.

Synthesis

Synthesis of tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate from 1-Boc-4-(4-Iodo-1H-pyrazol-1-yl)piperidine and 1-4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bi(1,3,2-dioxaborolane), which can also be obtained by purification and isolation from tert-Butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate.

 or

References

[1] Patent: WO2014/193647, 2014, A2. Location in patent: Paragraph 0185
[2] Patent: CN104119331, 2018, B. Location in patent: Paragraph 0382; 0390; 0391
[3] Patent: WO2010/68292, 2010, A1. Location in patent: Page/Page column 85-86
[4] Patent: WO2014/89280, 2014, A1. Location in patent: Page/Page column 50
[5] Patent: CN103833753, 2017, B. Location in patent: Paragraph 0352; 0358; 0359

tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Suppliers

Americas 1 China 317 Europe 1 India 4 Japan 1 United Kingdom 3 United States 16 Global 343
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl] piperidine-1-carboxylate 877399-74-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-28
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate 877399-74-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞98% by HPLC
Supply Ability
10kg/month
Release date
2023-01-09
Henan Aochuang Chemical Co.,Ltd.
Product
tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate 877399-74-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

877399-74-1, tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylateRelated Search:

1,4-Dioxane Diethylene glycol monobutyl ether Cyhalofop-butyl Pyrazole Butyl acetate 2-Chloro-2-methylpropane Haloperidol Selenium dioxide Buprofezin tert-Butanol 2-Butoxyethanol Butyl acrylate tert-Butyl 4-broMo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (R)-1-Boc-2-cyanopyrrolidine 1-N-Boc-3-hydroxyazetidine 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 1-Boc-3-(cyanomethylene)azetidine

  • tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
  • 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
  • 1-(4-N-Boc-piperidine)pyrazole-4-boronic acid pinacol ester
  • <i>tert</i>-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
  • tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-car
  • Crizotinib intermediates 2
  • 1-Piperidinecarboxylic acid, 4
  • Borate fragment of crizotinib
  • Crizotinib Impurity 2
  • 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylatetert-Butyl
  • 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL) -1H-PYRAZOL-1-YL]PIPERIDINE-1-CARBOXYLATE_ 877399-74-1
  • 1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid picol ester
  • 1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
  • 1-(1-Boc-4-piperidyl)pyrazole-4-boronic acid pinacol ester
  • 4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-yl]-piperidine-1-carboxylic acid tert-butyl ester
  • 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl)piperidine-1-carb
  • tert-butyl 4-(4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H
  • 1-Piperidinecarboxylic acid, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazol-1-yl]-, 196%
  • tert-Butyl 4-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxyla
  • 5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine
  • 4-(4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL-1-YL)PIPERIDINE-1-CARBOXYLATE
  • tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carbox
  • 1-(1-Boc-piperidin-4-yl)-pyrazole-4-boronic acid pinacol ester
  • tert-butyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
  • tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate
  • tert-butyl 4-(3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrol-1-yl)piperidine-1-carboxylate
  • InterMediate Ⅱ of Crizotinib
  • tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate &gt
  • 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
  • tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-
  • 4 - [4 - (4 - (4,4,5,5 31 - methyl - 1-2 oxygen mixed boron borane - 2 - base) - 1 h - pyrazole - 1 - base] piperidine - 1 - formic acid tert-butyl ester
  • 2-[1-(1-Boc-piperidin-4-yl)pyrazol-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate ISO 9001：2015 REACH
  • Crizotinib Impurity 1
  • tert-butyl 4-(4-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
  • 1-(N-Boc-piperidine-4-ly)-boronicacid pinacol ester
  • CrizotinibIntermediate4
  • 1-(N-Boc-piperidin-4-yl)-1H-pyrazole-4-boronic acid pinacol ester
  • tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate , Crizotinib Impurity 5
  • 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylicacidtert-butylester
  • 1-[1-(tert-Butoxycarbonyl)piperidin-4-yl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
  • tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate - [B10044]
  • 877399-74-1
  • 977399-74-1
  • 977399-47-1
  • C19H32BN3O4