1-Boc-3-(cyanomethylene)azetidine

Uses

Product Name: 1-Boc-3-(cyanomethylene)azetidine
CAS No.: 1153949-11-1
Chemical Name: 1-Boc-3-(cyanomethylene)azetidine
Synonyms: tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate;benzyl 3-(cyanomethylene)azetidine-1-carboxylate;3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester;Baricitinib-013;Baricitinib Impurity 10;tert-Butyl 3-(cyanomethylene);1-Boc-3-(cyanomethylene)azetidine;P-Hydroxy phenyl butanone (Raspberry ketone);1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine;ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate
CBNumber: CB22485423
Molecular Formula: C10H14N2O2
Formula Weight: 194.23
MOL File: 1153949-11-1.mol

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1-Boc-3-(cyanomethylene)azetidine Property

Boiling point:: 309.7±35.0 °C(Predicted)
Density: 1.215
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: -1.88±0.20(Predicted)
color: White to Orange to Green

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Safety

RIDADR: UN 3439 6.1/PG III
HazardClass: 6.1
PackingGroup: III
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5217
Product name: 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity: >95.0%(GC)
Packaging: 200mg
Price: $52
Updated: 2024/03/01

TCI Chemical

Product number: B5217
Product name: 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity: >95.0%(GC)
Packaging: 1g
Price: $148
Updated: 2024/03/01

TRC

Product number: B117850
Product name: 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B117850
Product name: 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging: 25g
Price: $340
Updated: 2021/12/16

Apolloscientific

Product number: OR930876
Product name: tert-Butyl3-(cyanomethylene)azetidine-1-carboxylate
Purity: 95%
Packaging: 10g
Price: $135
Updated: 2021/12/16

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1-Boc-3-(cyanomethylene)azetidine Chemical Properties,Usage,Production

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

1-Boc-3-(cyanomethylene)azetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-(cyanomethylene)azetidine Suppliers

Americas 1 Canada 1 China 182 Europe 1 India 5 Japan 1 United Kingdom 1 United States 9 Global 201

Beijing Cooperate Pharmaceutical Co.,Ltd

Tel: +86-010-60279497 +86-15646567669
Fax: 010-60279497
Email: sales01@cooperate-pharm.com
Country: China
ProdList: 137
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 259
Advantage: 61

Shanghai Jin Yi Fine Chemical Co.,LTD

Tel: 021-52801082 13918092929
Fax: 021-52803959
Email: jinyi_service@jyfinechem.com
Country: China
ProdList: 41
Advantage: 57

BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015397 18862996710
Fax: 0513-68015394
Email: sales12@btcpharm.com
Country: China
ProdList: 689
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 4986
Advantage: 55

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9413
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

QINGDAO CARELONGPHARMATECH CO.,LTD

Tel: 0532-0532-88191853 13061484198
Email: sales@carelongchem.com
Country: China
ProdList: 411
Advantage: 57

Chengdu Pukang Biotechnology Co., Ltd

Tel: 028-82550498 19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 485
Advantage: 58

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View Lastest Price from 1-Boc-3-(cyanomethylene)azetidine manufacturers

Nanjing Fred Technology Co., Ltd

Product: 1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

R&D Scientific Inc.

Product: tert-butyl 3-(cyanomethylidene)azetidine-1-carboxylate 1153949-11-1
Price: US $880.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-04-05

Henan Fengda Chemical Co., Ltd

Product: 1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price: US $500.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000 ton/year
Release date: 2023-12-21

1153949-11-1, 1-Boc-3-(cyanomethylene)azetidineRelated Search:

3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester 1-N-Boc-3-hydroxyazetidine (R)-1-Boc-2-cyanopyrrolidine tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-pyrroline tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate tert-Butyl 4-broMo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate Baricitinib tert-butyl 3-oxidanyl-3-pyridin-2-yl-azetidine-1-carboxylate tert-butyl 4-((4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)Methyl)piperazine-1-carboxylate 1-Boc-Azetidine-3-yl-methanol tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate tert-butyl 2,2,4,8-tetraMethyl-1,2,3,4-tetrahydroquinolin-7-ylcarbaMate tert-butyl 3-(4-(7-carbamoyl-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)aMino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate

1-Boc-3-(cyanomethylene)azetidine

3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester

tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate

tert-butyl 3-(cyanoMethylidene)azetidine-1-carboxylate

3-(Cyanomethylene)-1-azetidinecarboxylic acid tert-butyl ester

1-(<i>tert</i>-Butoxycarbonyl)-3-(cyanomethylene)azetidine

P-Hydroxy phenyl butanone (Raspberry ketone)

tert-Butyl 3-(cyanomethylene)

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine

1-Azetidinecarboxylic acid, 3-(cyanomethylene)-, 1,1-dimethylethyl ester

Baricitinib Impurity 10

benzyl 3-(cyanomethylene)azetidine-1-carboxylate

Baricitinib-013

ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate

1153949-11-1