Uses
ChemicalBook > CAS DataBase List > 1-Boc-3-(cyanomethylene)azetidine

1-Boc-3-(cyanomethylene)azetidine

Uses
Product Name
1-Boc-3-(cyanomethylene)azetidine
CAS No.
1153949-11-1
Chemical Name
1-Boc-3-(cyanomethylene)azetidine
Synonyms
tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate;benzyl 3-(cyanomethylene)azetidine-1-carboxylate;3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester;Baricitinib-013;Baricitinib Impurity 10;tert-Butyl 3-(cyanomethylene);1-Boc-3-(cyanomethylene)azetidine;P-Hydroxy phenyl butanone (Raspberry ketone);1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine;ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate
CBNumber
CB22485423
Molecular Formula
C10H14N2O2
Formula Weight
194.23
MOL File
1153949-11-1.mol
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1-Boc-3-(cyanomethylene)azetidine Property

Boiling point:
309.7±35.0 °C(Predicted)
Density 
1.215
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to crystal
pka
-1.88±0.20(Predicted)
color 
White to Orange to Green
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Safety

RIDADR 
UN 3439 6.1/PG III
HazardClass 
6.1
PackingGroup 
III
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5217
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity
>95.0%(GC)
Packaging
200mg
Price
$52
Updated
2024/03/01
TCI Chemical
Product number
B5217
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Purity
>95.0%(GC)
Packaging
1g
Price
$148
Updated
2024/03/01
TRC
Product number
B117850
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
B117850
Product name
1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
Packaging
25g
Price
$340
Updated
2021/12/16
Apolloscientific
Product number
OR930876
Product name
tert-Butyl3-(cyanomethylene)azetidine-1-carboxylate
Purity
95%
Packaging
10g
Price
$135
Updated
2021/12/16
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1-Boc-3-(cyanomethylene)azetidine Chemical Properties,Usage,Production

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

1-Boc-3-(cyanomethylene)azetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-(cyanomethylene)azetidine Suppliers

Beijing Cooperate Pharmaceutical Co.,Ltd
Tel
+86-010-60279497 +86-15646567669
Fax
010-60279497
Email
sales01@cooperate-pharm.com
Country
China
ProdList
137
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
261
Advantage
61
Shanghai Jin Yi Fine Chemical Co.,LTD
Tel
021-52801082 13918092929
Fax
021-52803959
Email
jinyi_service@jyfinechem.com
Country
China
ProdList
41
Advantage
57
BTC Pharmaceutical CO. Ltd
Tel
0513-0513-68015397 18862996710
Fax
0513-68015394
Email
sales12@btcpharm.com
Country
China
ProdList
692
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
QINGDAO CARELONGPHARMATECH CO.,LTD
Tel
0532-0532-88191853 13061484198
Email
sales@carelongchem.com
Country
China
ProdList
413
Advantage
57
Chengdu Pukang Biotechnology Co., Ltd
Tel
028-82550498 19102685862
Fax
086-28-82550468
Email
sales@pu-kang.com
Country
China
ProdList
485
Advantage
58
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View Lastest Price from 1-Boc-3-(cyanomethylene)azetidine manufacturers

Nanjing Fred Technology Co., Ltd
Product
1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
R&D Scientific Inc.
Product
tert-butyl 3-(cyanomethylidene)azetidine-1-carboxylate 1153949-11-1
Price
US $880.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-04-05
Henan Fengda Chemical Co., Ltd
Product
1-Boc-3-(cyanomethylene)azetidine 1153949-11-1
Price
US $500.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2000 ton/year
Release date
2023-12-21

1153949-11-1, 1-Boc-3-(cyanomethylene)azetidineRelated Search:


  • 1-Boc-3-(cyanomethylene)azetidine
  • 3-Cyanomethylene-azetidine-1-carboxylic acid tert-butyl ester
  • tert-butyl 3-(cyanoMethylene)azetidine-1-carboxylate
  • tert-butyl 3-(cyanoMethylidene)azetidine-1-carboxylate
  • 3-(Cyanomethylene)-1-azetidinecarboxylic acid tert-butyl ester
  • 1-(<i>tert</i>-Butoxycarbonyl)-3-(cyanomethylene)azetidine
  • P-Hydroxy phenyl butanone (Raspberry ketone)
  • tert-Butyl 3-(cyanomethylene)
  • 1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine
  • 1-Azetidinecarboxylic acid, 3-(cyanomethylene)-, 1,1-dimethylethyl ester
  • Baricitinib Impurity 10
  • benzyl 3-(cyanomethylene)azetidine-1-carboxylate
  • Baricitinib-013
  • ert-butyl3-(cyanomethylidene)azetidine-1-carboxylate
  • 1153949-11-1