3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
- Product Name
- 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
- CAS No.
- 892414-47-0
- Chemical Name
- 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- SW-84;SWF-84;3--trifluoromethyl-7-azaindole;3-(trifluoroMethyl)-1H-pyrrolo[2,3;3-(Trifluoromethyl)-1H-pyrrolo[2,3-b];3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine;3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine-4;1H-Pyrrolo[2,3-b]pyridine, 3-(trifluoromethyl)-
- CBNumber
- CB22490128
- Molecular Formula
- C8H5F3N2
- Formula Weight
- 186.13
- MOL File
- 892414-47-0.mol
3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Property
- Density
- 1.447±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- pka
- 12.04±0.40(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T797280
- Product name
- 3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 1g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 3H32-3-2X
- Product name
- 3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 9031AF
- Product name
- 3-(Trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 5g
- Price
- $606
- Updated
- 2021/12/16
- Product number
- HCH0037549
- Product name
- 3-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-B]PYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1114.52
- Updated
- 2021/12/16
- Product number
- CM108953
- Product name
- 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%+
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties,Usage,Production
Synthesis
892414-46-9
892414-47-0
General procedure for the synthesis of 3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol from 3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine: At 0 °C, 3-(trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol (1.2 g, 5.88 mmol) was dissolved in a tetrahydrofuran (15 mL) and pyridine (0.951 mL, 11.76 mmol) in a mixed solution and thionyl chloride (0.858 mL, 11.76 mmol) was added slowly. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was poured into ice water and the pH was adjusted with saturated sodium carbonate solution to 6. Subsequently, the aqueous layer was extracted with dichloromethane, and the organic layers were combined and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated to dryness. For complete removal of residual pyridine, toluene was added and concentrated to dryness, and this operation was repeated three times to give 3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine as a brown solid (1.13 g, 100% yield). The mass spectrum (ESI) showed m/z = 186.88 (MH+).
References
[1] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 80
[2] Organic Process Research and Development, 2010, vol. 14, # 1, p. 168 - 173
[3] Synthesis, 2007, # 2, p. 251 - 258
[4] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 105
[5] Patent: WO2016/142310, 2016, A1. Location in patent: Page/Page column 72
3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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