ChemicalBook > CAS DataBase List > 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-

Product Name
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
CAS No.
23612-48-8
Chemical Name
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
Synonyms
SW-79;SWF-79;2-Methyl-7-azaindole;2-Methyl-7-aza-1H-indole;2-Methyl-7-azaindole 98%;2-Methyl-7-azaindole ,99%;2-Methyl-7-azaindole ,98.5%;2-Methyl-7-azaindole, 98.5%, 98.5%;2-METHYL-1H-PYRROLO[2,3-B]-PYRIDINE;1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
CBNumber
CB1821714
Molecular Formula
C8H8N2
Formula Weight
132.16
MOL File
23612-48-8.mol
More
Less

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- Property

Melting point:
136-142℃
Density 
1.17
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.45±0.40(Predicted)
color 
Brown
CAS DataBase Reference
23612-48-8
More
Less

Safety

HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
M321420
Product name
2-Methyl-7-Azaindole
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
M321420
Product name
2-Methyl-7-Azaindole
Packaging
500mg
Price
$85
Updated
2021/12/16
Matrix Scientific
Product number
068846
Product name
2-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity
>95%
Packaging
1g
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-33
Product name
2-Methyl-7-azaindole
Purity
95%
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
068846
Product name
2-Methyl-1H-pyrrolo[2,3-b]pyridine
Purity
>95%
Packaging
5g
Price
$195
Updated
2021/12/16
More
Less

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

2-Methyl-7-Azaindole can be used to fingerprint volatile profile of traditional tobacco and e-cigarettes.

Synthesis

78191-00-1

138343-75-6

23612-48-8

Under nitrogen protection, tert-butyl 3-methylpyridin-2-ylcarbamate (5.07 g, 23.6 mmol) was dissolved in 100 mL of tetrahydrofuran and the mixture was cooled to -10 °C. Under stirring, n-butyllithium (2.5 M hexane solution, 28 mL, 70 mmol) was slowly added over 15 min and the reaction solution turned dark red, and stirring was continued at -10 °C for 1 hr. Subsequently, N-methoxy-N-methylacetamide (3.80 g, 35.7 mmol) was added and the mixture was warmed to room temperature and stirred for 1 hour. Upon completion of the reaction, the mixture was cooled again to -10 °C, the reaction was quenched with 13 mL of concentrated hydrochloric acid, and then stirred at 50 °C for 90 min. After the two-phase mixture was cooled, the organic phase was separated and extracted twice with 2N hydrochloric acid. The aqueous phases were combined, alkalized to the proper pH with 32% sodium hydroxide solution and subsequently extracted three times with ethyl acetate. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by Isolera purification system (ethyl acetate-hexane gradient, 0:100 ascending to 50:50) to afford 2-methyl-7-azaindole (2.5 g, 18.9 mmol, 80% yield) as a light yellow solid with 100% purity.1H NMR (400 MHz, CDCl3) δ ppm 2.55 (s, 3H, Me) 6.17 (s, 1H, H-3), 7.03 (dd, J = 4.9, 7.6 Hz, 1H, H-5), 7.82 (d, J = 7.4 Hz, 1H, H-4), 8.21 (d, J = 4.7 Hz, 1H, H-6), 11.96 (br.s, 1H, NH).UPLC/MS (3 min) retention time 0.68 min. LRMS: m/z 133 (M + 1).

References

[1] European Journal of Medicinal Chemistry, 2016, vol. 113, p. 102 - 133

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- Preparation Products And Raw materials

Raw materials

Hexane N-Methylaniline Di-tert-butyl dicarbonate 2-Amino-3-picoline Isopropyl acetate Tetrahydrofuran Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide L(+)-Tartaric acid N,N-Dimethylacetamide n-Butyllithium

Preparation Products

More
Less

1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- Suppliers

Canada 1 China 129 Germany 1 India 1 United Kingdom 1 United States 9 Global 142
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
More
Less

View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- manufacturers

Career Henan Chemical Co
Product
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- 23612-48-8
Price
US $1.00/KG
Min. Order
1IU
Purity
99%
Supply Ability
1kg-1000kg
Release date
2020-01-03

23612-48-8, 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-Related Search:

BOC,BZL-L-ALA-OH Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI) 1H-Pyrrole-2-acetic acid, 3-(methoxycarbonyl)-1-methyl-, methyl ester 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 6-Bromoisatin 7-bromo-4-(trifluoromethyl)-1H-indole 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 3-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER SW-80 methyl exo-3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride LY-2484595 (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester 1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine, 2,3-dimethyl- 2-(TERT-BUTYL)-1H-PYRROLO[2,3-B]PYRIDINE 2,4-DIMETHYL-A-CARBOLINE 2-phenyl-1H-pyrrolo[2,3-b]pyridine [1-(PHENYLSULFONYL)-1H-PYRROLO[2,3-B]PYRIDIN-2-YL](2-THIENYL)METHANOL

  • 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
  • 2-METHYL-1H-PYRROLO[2,3-B]-PYRIDINE
  • 2-Methyl-7-azaindole
  • 2-Methyl-7-azaindole ,99%
  • 2-Methyl-7-azaindole ,98.5%
  • 2-Methyl-7-azaindole, 98.5%, 98.5%
  • SWF-79
  • SW-79
  • 2-Methyl-7-azaindole 98%
  • 2-Methyl-7-aza-1H-indole
  • 23612-48-8
  • Azaindoles