LY-2484595

Product Name: LY-2484595
CAS No.: 1186486-62-3
Chemical Name: LY-2484595
Synonyms: SW-86;CS-653;SWF-86;LY-2484595;Evacetrapib;Evacetrapib, >=98%;LY-2484595 USP/EP/BP;LY-2484595 Evacetrapib;Evacetrapib (LY2484595);LY2484595; LY 2484595; LY-2484595
CBNumber: CB82516031
Molecular Formula: C31H36F6N6O2
Formula Weight: 638.65
MOL File: 1186486-62-3.mol

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LY-2484595 Property

Boiling point:: 680.1±65.0 °C(Predicted)
Density: 1.40
storage temp.: Store at -20°C
solubility: ≥32.1 mg/mL in DMSO; insoluble in H2O; ≥50.4 mg/mL in EtOH with ultrasonic
form: solid
pka: 4.73±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H361Suspected of damaging fertility or the unborn child

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23670
Product name: Evacetrapib
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23670
Product name: Evacetrapib
Purity: ≥98%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 23670
Product name: Evacetrapib
Purity: ≥98%
Packaging: 50mg
Price: $475
Updated: 2024/03/01

Cayman Chemical

Product number: 23670
Product name: Evacetrapib
Purity: ≥98%
Packaging: 100mg
Price: $790
Updated: 2024/03/01

TRC

Product number: E945200
Product name: Evacetrapib
Packaging: 25mg
Price: $250
Updated: 2021/12/16

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LY-2484595 Chemical Properties,Usage,Production

Uses

Evacetrapib is an inhibitor of?cholesteryl ester transfer protein (CETP). CETP catalyzes the exchange of cholesteryl ester and triglyceride between lipoproteins and modulates HDL cholesterol levels in plasma. CETP inhibitors are potential compounds for treating coronary artery disease.

Definition

ChEBI: Evacetrapib is a benzazepine.

Biological Activity

evacetrapib is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) with ic50 value of 5.5nm [1].as a benzazepine-based inhibitor of cetp, evacetrapib is developed to increase hdl cholesterol for the treatment of coronary artery disease. evacetrapib is efficacious both in vitro and in vivo. the ic50 values of evacetrapib against cetp are 5.5nm and 26nm, respectively in the buffer assay using human recombinant cetp and in the plasma assay using human plasma cetp. in the animal model of human cetp/apoai double transgenic mouse line, oral administration of evacetrapib at 30mg/kg significantly inhibits the cetp activity as well as increases the level of hdl. besides that, the ed50 value of evacetrapib is less than 5mg/kg. compared to the previous inhibitors of cetp, evacetrapib has less side effects. it is found no to increase blood pressure zucker diabetic fatty rats and not to induce aldosterone or cortisol synthesis in h295r cells [1].

target

CETP

References

[1] cao g, beyer tp, zhang y, schmidt rj, chen yq, cockerham sl, zimmerman km, karathanasis sk, cannady ea, fields t, mantlo nb. evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates hdl cholesterol without inducing aldosterone or increasing blood pressure. j lipid res. 2011 dec;52(12):2169-76.

LY-2484595 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2484595 Suppliers

China 101 India 4 United States 16 Global 121

Shanghai Boyle Chemical Co., Ltd.

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EnliPharma Technology Co., Ltd

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View Lastest Price from LY-2484595 manufacturers

Career Henan Chemical Co

Product: LY-2484595 1186486-62-3
Price: US $1.00-2.00/KG
Min. Order: 1KG
Purity: 95.0-99.8%
Supply Ability: 1KG;5KG 10KG; 100KG
Release date: 2019-09-02

1186486-62-3, LY-2484595Related Search:

3-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 7-bromo-4-(trifluoromethyl)-1H-indole 6-Bromoisatin 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrole-2-acetic acid, 3-(methoxycarbonyl)-1-methyl-, methyl ester Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI) 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- BOC,BZL-L-ALA-OH TRANS-STILBENE Ezetimibe (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid PCI 34051 Probucol IPI 145 CAL-101 (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester methyl exo-3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride

LY-2484595

Evacetrapib

trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid

(1S,4r)-4-(((S)-5-((3,5-bis(trifluoroMethyl)benzyl)(2-Methyl-2H-tetrazol-5-yl)aMino)-7,9-diMethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)Methyl)cyclohexanecarboxylic acid

Evacetrapib (LY2484595)

Cyclohexanecarboxylic acid, 4-[[(5S)-5-[[[3,5-bis(trifluoroMethyl)phenyl]Methyl](2-Methyl-2H-tetrazol-5-yl)aMino]-2,3,4,5-tetrahydro-7,9-diMethyl-1H-1-benzazepin-1-yl]Methyl]-, trans-

Evacetrapib, >=98%

EVACETRAPIB (LY2484595);LY2484595;LY 2484595;LY-2484595

(1S,4r)-4-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimet

LY-2484595 Evacetrapib

LY2484595; LY 2484595; LY-2484595

4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylicacid

CS-653

LY-2484595 USP/EP/BP

SWF-86

SW-86

4-trans-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid

1186486-62-3

C31H36F6N6O2

Inhibitors

Inhibitor