PCI 34051

Product Name: PCI 34051
CAS No.: 950762-95-5
Chemical Name: PCI 34051
Synonyms: PCI-34051;PCI 34051;PCI-34051;PCI 34051;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-
CBNumber: CB52622953
Molecular Formula: C17H16N2O3
Formula Weight: 296.32
MOL File: 950762-95-5.mol

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PCI 34051 Property

Density: 1.25
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
form: Powder
pka: 9.16±0.30(Predicted)
color: White to gray

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 5mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 50mg
Price: $602
Updated: 2024/03/01

Cayman Chemical

Product number: 10444
Product name: PCI 34051
Purity: ≥95%
Packaging: 100mg
Price: $829
Updated: 2024/03/01

Tocris

Product number: 4643
Product name: PCI34051
Purity: ≥98%(HPLC)
Packaging: 50
Price: $471
Updated: 2021/12/16

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PCI 34051 Chemical Properties,Usage,Production

Uses

PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Definition

ChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.

Biological Activity

pci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.

storage

-20°C

PCI 34051 Preparation Products And Raw materials

Raw materials

Preparation Products

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PCI 34051 Suppliers

Canada 1 China 100 India 2 United Kingdom 1 United States 18 Global 122

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

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View Lastest Price from PCI 34051 manufacturers

Career Henan Chemical Co

Product: N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

Career Henan Chemical Co

Product: N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide 950762-95-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

950762-95-5, PCI 34051Related Search:

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N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide

PCI 34051

PCI-34051

1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide

1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-

N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

PCI-34051;PCI 34051

N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide

950762-95-5

Apoptosis

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitor