ChemicalBook > CAS DataBase List > LY-2484595

LY-2484595

Product Name
LY-2484595
CAS No.
1186486-62-3
Chemical Name
LY-2484595
Synonyms
SW-86;CS-653;SWF-86;LY-2484595;Evacetrapib;Evacetrapib, >=98%;LY-2484595 USP/EP/BP;LY-2484595 Evacetrapib;Evacetrapib (LY2484595);LY2484595; LY 2484595; LY-2484595
CBNumber
CB82516031
Molecular Formula
C31H36F6N6O2
Formula Weight
638.65
MOL File
1186486-62-3.mol
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LY-2484595 Property

Boiling point:
680.1±65.0 °C(Predicted)
Density 
1.40
storage temp. 
Store at -20°C
solubility 
≥32.1 mg/mL in DMSO; insoluble in H2O; ≥50.4 mg/mL in EtOH with ultrasonic
form 
solid
pka
4.73±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H361Suspected of damaging fertility or the unborn child

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23670
Product name
Evacetrapib
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23670
Product name
Evacetrapib
Purity
≥98%
Packaging
10mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
23670
Product name
Evacetrapib
Purity
≥98%
Packaging
50mg
Price
$475
Updated
2024/03/01
Cayman Chemical
Product number
23670
Product name
Evacetrapib
Purity
≥98%
Packaging
100mg
Price
$790
Updated
2024/03/01
TRC
Product number
E945200
Product name
Evacetrapib
Packaging
25mg
Price
$250
Updated
2021/12/16
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LY-2484595 Chemical Properties,Usage,Production

Uses

Evacetrapib is an inhibitor of?cholesteryl ester transfer protein (CETP). CETP catalyzes the exchange of cholesteryl ester and triglyceride between lipoproteins and modulates HDL cholesterol levels in plasma. CETP inhibitors are potential compounds for treating coronary artery disease.

Definition

ChEBI: Evacetrapib is a benzazepine.

Biological Activity

evacetrapib is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) with ic50 value of 5.5nm [1].as a benzazepine-based inhibitor of cetp, evacetrapib is developed to increase hdl cholesterol for the treatment of coronary artery disease. evacetrapib is efficacious both in vitro and in vivo. the ic50 values of evacetrapib against cetp are 5.5nm and 26nm, respectively in the buffer assay using human recombinant cetp and in the plasma assay using human plasma cetp. in the animal model of human cetp/apoai double transgenic mouse line, oral administration of evacetrapib at 30mg/kg significantly inhibits the cetp activity as well as increases the level of hdl. besides that, the ed50 value of evacetrapib is less than 5mg/kg. compared to the previous inhibitors of cetp, evacetrapib has less side effects. it is found no to increase blood pressure zucker diabetic fatty rats and not to induce aldosterone or cortisol synthesis in h295r cells [1].

target

CETP

References

[1] cao g, beyer tp, zhang y, schmidt rj, chen yq, cockerham sl, zimmerman km, karathanasis sk, cannady ea, fields t, mantlo nb. evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates hdl cholesterol without inducing aldosterone or increasing blood pressure. j lipid res. 2011 dec;52(12):2169-76.

LY-2484595 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2484595 Suppliers

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View Lastest Price from LY-2484595 manufacturers

Career Henan Chemical Co
Product
LY-2484595 1186486-62-3
Price
US $1.00-2.00/KG
Min. Order
1KG
Purity
95.0-99.8%
Supply Ability
1KG;5KG 10KG; 100KG
Release date
2019-09-02

1186486-62-3, LY-2484595Related Search:

3-BROMO-1H-PYRROLE-2-CARBOXYLIC ACID METHYL ESTER 2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine 7-bromo-4-(trifluoromethyl)-1H-indole 6-Bromoisatin 3-Trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrole-2-acetic acid, 3-(methoxycarbonyl)-1-methyl-, methyl ester Pyrido[4,3-d]pyrimidin-4(1H)-one (9CI) 1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL- BOC,BZL-L-ALA-OH TRANS-STILBENE Ezetimibe (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid PCI 34051 Probucol IPI 145 CAL-101 (1s,3r,4r)-3-[(tert-butoxycarbonyl)amino]-4-[(methylsulfonyl)oxy]cyclohexanecarboxylic acid ethyl ester methyl exo-3-azabicyclo[3.1.0]hexane-6-carboxylate hydrochloride

  • LY-2484595
  • Evacetrapib
  • trans-4-[[(5S)-5-[[[3,5-Bis(trifluoromethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]cyclohexanecarboxylic acid
  • (1S,4r)-4-(((S)-5-((3,5-bis(trifluoroMethyl)benzyl)(2-Methyl-2H-tetrazol-5-yl)aMino)-7,9-diMethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)Methyl)cyclohexanecarboxylic acid
  • Evacetrapib (LY2484595)
  • Cyclohexanecarboxylic acid, 4-[[(5S)-5-[[[3,5-bis(trifluoroMethyl)phenyl]Methyl](2-Methyl-2H-tetrazol-5-yl)aMino]-2,3,4,5-tetrahydro-7,9-diMethyl-1H-1-benzazepin-1-yl]Methyl]-, trans-
  • Evacetrapib, >=98%
  • EVACETRAPIB (LY2484595);LY2484595;LY 2484595;LY-2484595
  • (1S,4r)-4-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimet
  • LY-2484595 Evacetrapib
  • LY2484595; LY 2484595; LY-2484595
  • 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylicacid
  • CS-653
  • LY-2484595 USP/EP/BP
  • SWF-86
  • SW-86
  • 4-trans-(((S)-5-((3,5-Bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid
  • 1186486-62-3
  • C31H36F6N6O2
  • Inhibitors
  • Inhibitor