ChemicalBook > CAS DataBase List > lurasidone

lurasidone

Drug for the treatment of schizophrenia

Product Name: lurasidone
CAS No.: 367514-87-2
Chemical Name: lurasidone
Synonyms: CS-327;urasidone;lurasidone;Luclazepam;Lurasindone;D8-Lurasidone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);Lurasidone Free base
CBNumber: CB22498821
Molecular Formula: C28H36N4O2S
Formula Weight: 492.68
MOL File: 367514-87-2.mol

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lurasidone Property

Melting point:: 146-149°C
Boiling point:: 623.4±55.0 °C(Predicted)
Density: 1.273
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka: 8.41±0.50(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
InChIKey: PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES: C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
CAS DataBase Reference: 367514-87-2

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Safety

Hazardous Substances Data: 367514-87-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0280
Product name: Lurasidone
Packaging: 250MG
Price: $80
Updated: 2025/07/31

Cayman Chemical

Product number: 9000570
Product name: Lurasidone
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 9000570
Product name: Lurasidone
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 9000570
Product name: Lurasidone
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 9000570
Product name: Lurasidone
Purity: ≥98%
Packaging: 25mg
Price: $412
Updated: 2024/03/01

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lurasidone Chemical Properties,Usage,Production

Drug for the treatment of schizophrenia

Lurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.
The above information is edited by the Chemicalbook of Tian Ye.

Description

The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D₂ (K_i= 1.7 nM) and 5-HT_2A (K_i= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT_1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT₇ receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H₁ receptors and its weak affinity for the 5-HT_2C receptor. Antagonism at H₁ and 5-HT_2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.

Originator

Dainippon Sumitomo Pharma (Japan)

Definition

ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.

brand name

Latuda

lurasidone Preparation Products And Raw materials

Raw materials

Preparation Products

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lurasidone Suppliers

China 209 China Hong Kong 1 Europe 1 India 12 Japan 1 United States 11 Global 235

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View Lastest Price from lurasidone manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: lurasidone 367514-87-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200KG/M
Release date: 2023-08-15

Dideu Industries Group Limited

Product: lurasidone 367514-87-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-23

Longyan Tianhua Biological Technology Co., Ltd

Product: lurasidone 367514-87-2
Price: US $15.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-02

367514-87-2, lurasidoneRelated Search:

ILOPERIDONE dihydro-o-xylene 3-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1,2-benzothiazole (3aR,4S,7R,7aS)-2-{(1R,2S)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl}hexahydro-4,7-Methano-2H-isoindole-1,3-dione hydrochloride (3aR,4S,7R,7aS)-2-[[(1S,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione MAVBUKOHERNHBQ-UHFFFAOYSA-N Lurasidone Impurity 24 MDYJLJKDGQUHSJ-HTWOXQOSSA-N Nsc237999 Lurasidone Impurity 2 Lurasidon hydrochloride iMpurity s,s-endo-lurasidone HCl Pregabalin Liraglutide Lurasidone hydrochloride Lurasidone D8 HCl Lurasidone metabolite 14326 Lurasidone Inactive Metabolite 14283

4-{[(1R,2R)-2-{[4-(2$l^{4}-thia-6-azatricyclo[5.4.0.0^{2,6}]undeca-1(11),2,4,7,9-pentaen-5-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}-4-azatricyclo[5.2.1.0^{2,6}]deca-1(9),2(6),7-triene-3,5-dione

lurasidone

(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

Lurasidone (SM13496)

(3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4,7-Methanoisoindole-1,3(2H)-dione

urasidone

Lurasidone, >=98%

Lurasidone Base

(3aR,4S,7R,7aS)-2-((1R,2R)-2-(4-(1,2-Benzothiazol-3-yl)piperazin-1-ylmethyl)cyclohexylmethyl)hexahydro-4,7-methano-2H-isoindole-1,3-dione

SM13496; SM-13496; SM 13496

Lurasidone Free base

Lurasindone

CS-327

4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-

(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

lurasidone USP/EP/BP

TIANFU-CHEM - lurasidone

(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinylChemicalbook]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione

(3aR,4S,7R,7aS)-2-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]Methyl}cyclohexyl]Methyl}hexahydro-1H-4

Lurasidone (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1-yl)methyl) cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)- dione

(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3- yl)piperazin-1-yl]methyl}-cyclohexyl]methyl}-4- azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione

Luclazepam

D8-Lurasidone

367514-87-2

C28H36N4O2S

Pharmaceutical intermediate