lurasidone
Drug for the treatment of schizophrenia- Product Name
- lurasidone
- CAS No.
- 367514-87-2
- Chemical Name
- lurasidone
- Synonyms
- CS-327;urasidone;lurasidone;Lurasindone;Lurasidone Base;Lurasidone, >=98%;Lurasidone (SM13496);Lurasidone Free base;lurasidone USP/EP/BP;TIANFU-CHEM - lurasidone
- CBNumber
- CB22498821
- Molecular Formula
- C28H36N4O2S
- Formula Weight
- 492.68
- MOL File
- 367514-87-2.mol
lurasidone Property
- Melting point:
- 146-149°C
- Boiling point:
- 623.4±55.0 °C(Predicted)
- Density
- 1.273
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 8.41±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
- InChIKey
- PQXKDMSYBGKCJA-CVTJIBDQSA-N
- SMILES
- C1(=O)[C@]2([H])[C@@]([H])([C@]3([H])C[C@@]2([H])CC3)C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(C2C3=C(SN=2)C=CC=C3)CC1
- CAS DataBase Reference
- 367514-87-2
Safety
- Hazardous Substances Data
- 367514-87-2(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 9000570
- Product name
- Lurasidone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 9000570
- Product name
- Lurasidone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 9000570
- Product name
- Lurasidone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 9000570
- Product name
- Lurasidone
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $412
- Updated
- 2024/03/01
- Product number
- L474958
- Product name
- Lurasidone
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
lurasidone Chemical Properties,Usage,Production
Drug for the treatment of schizophrenia
Lurasidone is developed by Japan's Dainippon Sumitomo Pharma which is an atypical antipsychotic,and is a classification of drug registration 3.1 class, it is suitable for the treatment of patients with schizophrenia. Its efficacy is Determined in four six weeks in adult patients with schizophrenia controlled studies. The exact mechanism of the treatment of schizophrenia, like other atypical antipsychotics ,is not very clear,and may be related to the antagonism of the dopamine D2 and serotonin 2A (5-HT2A) receptors. For the treatment of schizophrenia, a study has reported lurasidone can improve cognitive function.
October 28, 2010 ,the FDA approved lurasidone hydrochloride (lurasidone HCI) tablets once a day for the first-line treatment of patients with schizophrenia, the trade name is Latuda.
Dosage: The recommended starting dose is 40 mg/d, the effective dose range is 40~120 mg /· d, the maximum recommended dose is 80 mg /· d. It should be taken with food.
Adverse reaction: common adverse reactions are somnolence, akathisia, nausea, Parkinson's disease-like symptoms and emotional anxiety. Lurasidone has no physical dependence, less likely to cause weight gain, it does not cause glucose, lipids (lipids), it changs the period between ECG and QT.
The above information is edited by the Chemicalbook of Tian Ye.
Description
The atypical antipsychotic lurasidone (also known as SM-13496) was approved in the United States in 2010 as an oral agent for the treatment of patients with schizophrenia. Lurasidone has potent affinity for D2 (Ki= 1.7 nM) and 5-HT2A (Ki= 2.0 nM) receptors and acts as an antagonist at both receptors. It is also a partial agonist at the 5-HT1A receptor and, unlike other atypical agents, is a potent antagonist at the 5-HT7 receptor; both of these activities are thought to confer beneficial cognitive properties. Lurasidone is further differentiated by its lack of affinity for muscarinic and histamine H1 receptors and its weak affinity for the 5-HT2C receptor. Antagonism at H1 and 5-HT2C receptors has been implicated in weight gain associated with atypical agents, while muscarinic receptor antagonism is associated with cognitive deficits.
Originator
Dainippon Sumitomo Pharma (Japan)
Definition
ChEBI: An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-m thanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizoph enia.
brand name
Latuda
lurasidone Preparation Products And Raw materials
Raw materials
Preparation Products
lurasidone Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from lurasidone manufacturers
- Product
- lurasidone 367514-87-2
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200KG/M
- Release date
- 2023-08-15
- Product
- Lurasidone 367514-87-2
- Price
- US $30.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 500
- Release date
- 2024-05-16
- Product
- lurasidone 367514-87-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23