Lurasidone hydrochloride

Product Name: Lurasidone hydrochloride
CAS No.: 367514-88-3
Chemical Name: Lurasidone hydrochloride
Synonyms: Lurasidonhydrochloride;Lurasidon hcl;(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride;CS-864;lurasidone HCI;Latuda, SM 13496;urasidone HydrochL;Exodiene Lurasidone;Lurasidonhydrochlorid;Lurasidone Hydrochlorid
CBNumber: CB32500192
Molecular Formula: C28H37ClN4O2S
Formula Weight: 529.14
MOL File: 367514-88-3.mol

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Lurasidone hydrochloride Property

Melting point:: 198-205°C
Flash point:: 9℃
storage temp.: Refrigerator
solubility: DMSO : 10 mg/mL (18.90 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
color: White to off-white
InChI: InChI=1/C28H36N4O2S.ClH/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26;/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2;1H/t18-,19+,20-,21-,24+,25-;/s3
InChIKey: PQXKDMSYBGKCJA-CVTJIBDQSA-N
SMILES: O=C1N(C(=O)[C@@]2([H])[C@]3([H])CC[C@@]([H])(C3)[C@@]12[H])C[C@@H]1CCCC[C@H]1CN1CCN(C2=NSC3=CC=CC=C23)CC1.Cl |&1:5,7,11,14,17,22,r|

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2069
Product name: Lurasidone hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10 mg
Price: $135
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2069
Product name: Lurasidone hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50 mg
Price: $545
Updated: 2025/07/31

Sigma-Aldrich

Product number: L-030
Product name: Lurasidone hydrochloride solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $200
Updated: 2025/07/31

TCI Chemical

Product number: L0457
Product name: Lurasidone Hydrochloride
Packaging: 1G
Price: $255
Updated: 2025/07/31

TRC

Product number: L474920
Product name: LurasidoneHydrochloride
Packaging: 5mg
Price: $180
Updated: 2021/12/16

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Lurasidone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively

Uses

An antipsychotic used for treatment of schizophrenia.

Definition

ChEBI: A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia.

Biological Activity

Lurasidone is an atypical antipsychotic, used clinically for treatment of schizophrenia and bi-polar disorder. It has nanomolar activity as an antagonist at dopamine D2, serotonin 5-HT2A, 5-HT7, and α2C-adrenergic receptors and as an agonist at 5-HT1A receptors.

Synthesis

186204-37-5

14805-29-9

367514-88-3

(3aR,7aR)-4'-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindol-2,1'-piperazin]-2-ium methanesulfonate (Intermediate 4, 28.8 kg, 66.2 mol) and (3aR,4S,7R,7aS)-rel-hexahydro-1H-4,7-bridged methylidene isoindole-1,3(2H)-dione (Intermediate 5. 12.0 kg, 72.8 mol) as raw material and potassium carbonate (11.0 kg, 79.7 mol) as base were suspended in toluene (270 L). The resulting suspension was heated and refluxed at 105 °C for 15 h. The reaction process was monitored by UPLC. Upon completion of the reaction, the reaction mixture was cooled to room temperature and quenched by the addition of water (90 L). The organic and aqueous phases were separated and the organic phase was concentrated to a smaller volume. Subsequently, the concentrated organic phase was treated with hydrochloric acid in isopropanol to afford the target product (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3- yl)piperazin-1- yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride ( Lurasidone hydrochloride, 34.4 kg, yield 98.3%, HPLC purity 99.49%).

References

[1] Patent: WO2015/56205, 2015, A1. Location in patent: Page/Page column 14
[2] Patent: WO2013/121440, 2013, A1

Lurasidone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Lurasidone hydrochloride Suppliers

Canada 1 China 315 India 22 United Kingdom 1 United States 14 Global 353

Hefei Topway Biotechnology Co.,Ltd

Tel: 0551-65326752 14755135869
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Country: China
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Jinan Jianfeng Chemical Co., Ltd.

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Jinan Baozhao Pharmaceutical Technology Co., Ltd.

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Country: China
ProdList: 159
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Jinan Million Pharmaceutical Co., Ltd

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Country: China
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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JinYan Chemicals(ShangHai) Co.,Ltd.

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Country: China
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Suzhou Zehou Biotechnology Co. , Ltd.

Tel: 0512-68716880 19984816880
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Country: China
ProdList: 212
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Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
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Country: China
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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
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View Lastest Price from Lurasidone hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Lurasidone hydrochloride 367514-88-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-24

Jinan Million Pharmaceutical Co., Ltd

Product: Lurasidone hydrochloride 367514-88-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200KG/M
Release date: 2023-08-11

Jinan Million Pharmaceutical Co., Ltd

Product: Luracidon hydrochloride 367514-88-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200KG
Release date: 2024-04-01

367514-88-3, Lurasidone hydrochlorideRelated Search:

(3aR,4S,7R,7aS)-2-{(1R,2S)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl}hexahydro-4,7-Methano-2H-isoindole-1,3-dione hydrochloride Lurasidon hydrochloride iMpurity Nsc237999 MDYJLJKDGQUHSJ-HTWOXQOSSA-N VILAZODONE Aprepitant ETOFIBRATE Posaconazole Defactinib MK-2206 2HCl PHA-665752 Imatinib mesylate Tozasertib Veliparib MAVBUKOHERNHBQ-UHFFFAOYSA-N s,s-endo-lurasidone HCl 3-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]-1,2-benzothiazole Lurasidone Amine Impurity

Lurasidonhydrochloride

Lurasidonhydrochlorid

(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride

(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride

Lurasidone Hydrochloride Tablets

Exodiene Lurasidone

Lurasidone HCl / Lurasidone Hydrochloride

(3aR,4R,7S,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)

CS-864

(1R,2S,3R,4S)-N-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylMethyl]-1-cyclohexylMethyl]-2,3-bicyclo[2.2.1]heptanedicarboxyiMide hydrochloride

Latuda, SM 13496

Lurasidone Hydrochlorid

(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylMethyl]cyclohexylMethyl]hexahydro-1H-4,7-Methanoisoindole-1,3-dione hydrochloride

Lurasidone Hydrochloride API

4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-, hydrochloride (1:1), (3aR,4S,7R,7aS)-

Lurasidone hydrochloride solution

SM-13496 (Hydrochloride)

urasidone HydrochL

(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione hydrochloride

(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-

Lurasidone hydrochloride USP/EP/BP

Lurasidon hcl

Lurasidone hydrochloride salt

(3aR,4S,7R,7aS)-2-{(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-yl methyl] cyclohexylmethyl}hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride

Lurasidone HCl (SM-13496)

(3aR,4S,7R,7aS)-2-[(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)pip...

urasidone hydrochloride

Lurasidone HydrochlorideQ: What is Lurasidone Hydrochloride Q: What is the CAS Number of Lurasidone Hydrochloride Q: What is the storage condition of Lurasidone Hydrochloride Q: What are the applications of Lurasidone Hydrochloride

lurasidone HCI

Lurasidone hydrochloride,SM13496,Inhibitor,5-hydroxytryptamine Receptor,Lurasidone,5-HT Receptor,Dopamine Receptor,inhibit,SM 13496,Serotonin Receptor

(R)-2-[[2-(4-aminophenyl ethyl] aminol-1-phenylethanol monohydrochloride

Luracidon hydrochloride

Lurasidone hydrochloride, 10 mM in DMSO

Lurasidone (hydrochloride) (CRM)

D8-Lurasidone Hydrochloride

367514-88-3

C28H36N4O2SHCl

C28H37ClN4O2S

Chiral Reagents

Intermediates & Fine Chemicals

Pharmaceuticals

367514-88-3

API