JAK3 Inhibitor
- Product Name
- JAK3 Inhibitor
- CAS No.
- 211555-04-3
- Chemical Name
- JAK3 Inhibitor
- Synonyms
- CS-1516;whi-p154cas;JAK3 Inhibitor;JAK3 Inhibitor II WHI-P154;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR
- CBNumber
- CB22502881
- Molecular Formula
- C16H14BrN3O3
- Formula Weight
- 376.2
- MOL File
- 211555-04-3.mol
JAK3 Inhibitor Property
- Melting point:
- 230 °C
- Boiling point:
- 470.3±45.0 °C(Predicted)
- Density
- 1.576±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble1mg/mL, clear (warmed)
- pka
- 8.57±0.31(Predicted)
- form
- powder
- color
- white to brown
- InChIKey
- CBIAKDAYHRWZCU-UHFFFAOYSA-N
- CAS DataBase Reference
- 211555-04-3
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- HS Code
- 2933.59.8000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 420104
- Product name
- JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem
- Packaging
- 5MG
- Price
- $303
- Updated
- 2024/03/01
- Product number
- W0013
- Product name
- WHI-P154
- Packaging
- 10MG
- Price
- $139
- Updated
- 2024/03/01
- Product number
- W0013
- Product name
- WHI-P154
- Packaging
- 50MG
- Price
- $417
- Updated
- 2024/03/01
- Product number
- 16178
- Product name
- WHI-P154
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 16178
- Product name
- WHI-P154
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $129
- Updated
- 2024/03/01
JAK3 Inhibitor Chemical Properties,Usage,Production
Description
WHI-
Uses
WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.
Uses
WHI-P154 can act as antileukemic agent with apoptosis inducing activity.
Biochem/physiol Actions
WHI-P154 is a specific inhibitor of JAK3 (IC50 = 1.8 μM) with no inhibitory activity against JAK1 or JAK2. WHI-P154 enhances myogenic differentiation of C2C12 mouse myoblast cells, and induces differentiation of neural progenitor cells. The compound WHI-P154 dose dependently inhibits expression of iNOS and NO production in LPS-challenged macrophages.
in vitro
kinase assays show that whi-p154 is not a specific inhibitor. besides jak3, it also inhibits many other kinases, including egfr, abl, lck, src and vegfr. whi-p154 inhibits egfr with ic50 value of 4nm. the specificity of whi-p154 has not been shown in cell-based assays either [1].
storage
Store at RT
References
[1] changelian ps, moshinsky d, kuhn cf, flanagan me, munchhof mj, harris tm, whipple da, doty jl, sun j, kent cr, magnuson ks, perregaux dg, sawyer ps, kudlacz em. the specificity of jak3 kinase inhibitors. blood. 2008 feb 15;111(4):2155-7.
[2] narla rk, liu xp, myers de, uckun fm. 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. clin cancer res. 1998 jun;4(6):1405-14.
JAK3 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
JAK3 Inhibitor Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from JAK3 Inhibitor manufacturers
- Product
- JAK3 Inhibitor 211555-04-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-24