5-Bromo-6-methoxypyridine-2-carboxylic acid
- Product Name
- 5-Bromo-6-methoxypyridine-2-carboxylic acid
- CAS No.
- 1214334-70-9
- Chemical Name
- 5-Bromo-6-methoxypyridine-2-carboxylic acid
- Synonyms
- 5-BroMo-6-Methoxypicolinic acid;5-Bromo-6-methoxypyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-bromo-6-methoxy-
- CBNumber
- CB22506935
- Molecular Formula
- C7H6BrNO3
- Formula Weight
- 232.03
- MOL File
- 1214334-70-9.mol
5-Bromo-6-methoxypyridine-2-carboxylic acid Property
- Boiling point:
- 323.8±42.0 °C(Predicted)
- Density
- 1.713±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 3.29±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H6BrNO3/c1-12-6-4(8)2-3-5(9-6)7(10)11/h2-3H,1H3,(H,10,11)
- InChIKey
- AIHBRPSPSCCVPH-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(OC)=C(Br)C=C1
Safety
- RIDADR
- UN2811
N-Bromosuccinimide Price
- Product number
- 3836AA
- Product name
- 5-Bromo-6-methoxypicolinicacid
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- HCH0367053
- Product name
- 5-BROMO-6-METHOXYPICOLINIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.39
- Updated
- 2021/12/16
- Product number
- 35934
- Product name
- 5-Bromo-6-methoxypicolinicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $612
- Updated
- 2021/12/16
- Product number
- 126202
- Product name
- 5-Bromo-6-methoxypicolinicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $1404
- Updated
- 2021/12/16
- Product number
- CM131102
- Product name
- 5-bromo-6-methoxypicolinicacid
- Purity
- 98%
- Packaging
- 25g
- Price
- $1763
- Updated
- 2021/12/16
5-Bromo-6-methoxypyridine-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
959958-25-9
124-41-4
1214334-70-9
Synthesis of 5-bromo-6-methoxypyridinecarboxylic acid: 5-bromo-6-chloropyridinecarboxylic acid (15.0 g, 63.4 mmol, 1.0 eq.) was suspended in methanol (130 mL) at room temperature, to which was added 4.37 M methanolic solution of sodium methanolate (58.0 mL, 253 mmol, 4.0 eq.). The reaction mixture was heated at 80 °C for 18 hours to form a thick mixture. Subsequently, the reaction mixture was diluted with methanol (100 mL) and stirring was continued at 80 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, acidified to pH=3 with concentrated aqueous hydrochloric acid, diluted with water and extracted with ethyl acetate (three times). The organic layers were combined, dried with magnesium sulfate, filtered and concentrated to give a residue. The residue was co-evaporated with dichloromethane/hexane (1:1 mixture, 200 mL, three times) to give the final 5-bromo-6-methoxypyridine carboxylic acid (13.9 g, 94% yield) as a white solid.1H NMR (500 MHz, CDCl3) δ 10.22 (br s, 1H), 8.06 (d, J = 7.7 Hz, 1H), 7.73 (d, J = 7.7 Hz, 1H), 4.10 (s, 3H).LCMS (ES-) [M-H]-: 229.9/231.9.
References
[1] Patent: WO2016/201168, 2016, A1. Location in patent: Paragraph 0174
5-Bromo-6-methoxypyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-6-methoxypyridine-2-carboxylic acid manufacturers
- Product
- 5-Bromo-6-methoxypyridine-2-carboxylic acid 1214334-70-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-05