ChemicalBook > CAS DataBase List > 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE

5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE

Product Name
5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE
CAS No.
399-00-8
Chemical Name
5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE
Synonyms
5-Bromo-4-fluorosalicylaldehyde;4-Fluoro-5-bromo-2-hydroxybenzaldehyde;5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE;Benzaldehyde, 5-bromo-4-fluoro-2-hydroxy-;5-Bromo-4-fluoro-2-hydroxybenzaldehyde 98%
CBNumber
CB2250799
Molecular Formula
C7H4BrFO2
Formula Weight
219.01
MOL File
Mol file
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5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE Property

Melting point:
81 °C
Boiling point:
256.6±35.0 °C(Predicted)
Density 
1.826±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
6.62±0.23(Predicted)
Appearance
Light yellow to pink Solid
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Safety

HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B678313
Product name
5-Bromo-4-fluoro-2-hydroxybenzaldehyde
Packaging
500mg
Price
$130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0366994
Product name
5-BROMO-4-FLUORO-2-HYDROXYBENZALDEHYDE
Purity
95.00%
Packaging
1G
Price
$223.65
Updated
2021/12/16
AK Scientific
Product number
5262AB
Product name
5-Bromo-4-fluoro-2-hydroxybenzaldehyde
Packaging
5g
Price
$316
Updated
2021/12/16
BroadPharm
Product number
BP-11735
Product name
5-bromo-4-fluoro-2-hydroxybenzaldehyde
Packaging
500mg
Price
$375
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-B-29
Product name
5-Bromo-4-fluoro-2-hydroxybenzaldehyde
Packaging
5G
Price
$396
Updated
2021/12/16
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5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE Chemical Properties,Usage,Production

Synthesis

348-28-7

399-00-8

The general procedure for the synthesis of 5-bromo-4-fluoro-2-hydroxybenzaldehyde using 4-fluoro-2-hydroxybenzaldehyde as starting material was as follows: a solution of bromine (14.1 g, 88.3 mmol) dissolved in chloroform (25 mL) was added slowly and dropwise over a period of 10 min to a solution of chloroform (68 mL) containing 4-fluoro-2-hydroxybenzaldehyde (13.6 g, 97.1 mmol) in a round bottomed flask. The reaction mixture was stirred at room temperature for 16 hours and then the same amount of bromine (14.1 g) was added. Stirring was continued at room temperature for 24 hours. Upon completion of the reaction, the mixture was washed twice with 30% aqueous sodium thiosulfate to remove the color, followed by washing with water and drying the organic layer with anhydrous sodium sulfate. Finally, the organic phase was concentrated by decompression to afford the target product 5-bromo-4-fluoro-2-hydroxybenzaldehyde (21.3 g, 100% yield).

References

[1] Patent: WO2012/40641, 2012, A2. Location in patent: Page/Page column 135; 136
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 12, p. 3163 - 3179
[3] Patent: US6642222, 2003, B2
[4] Patent: US6593335, 2003, B1
[5] Patent: WO2013/91096, 2013, A1. Location in patent: Page/Page column 37

5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE Suppliers

China 61 Germany 1 India 1 United Kingdom 3 United States 4 Global 70
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
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View Lastest Price from 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE 399-00-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-07
Henan Bao Enluo International TradeCo.，LTD
Product
5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE 399-00-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-08-17

399-00-8, 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDERelated Search:

5-bromo-2-chloroisonicotinaldehyde

  • 4-Fluoro-5-bromo-2-hydroxybenzaldehyde
  • 5-BROMO-4-FLUORO-2-HYDROXY-BENZALDEHYDE
  • 5-Bromo-4-fluoro-2-hydroxybenzaldehyde 98%
  • Benzaldehyde, 5-bromo-4-fluoro-2-hydroxy-
  • 5-Bromo-4-fluorosalicylaldehyde
  • 399-00-8