ChemicalBook > CAS DataBase List > Febuxostat-d9

Febuxostat-d9

Product Name: Febuxostat-d9
CAS No.: 1246819-50-0
Chemical Name: Febuxostat-d9
Synonyms: TMX 67-d9;TEI 6720-d9;Febuxostat-d;Febuxostat-d9;D9-Febuxostat;[2H9]-Febuxostat;Dapagliflozin Impurity 138;Febuxostat-d9 (2-methylpropoxy-d9);2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid;2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
CBNumber: CB22508843
Molecular Formula: C16H16N2O3S
Formula Weight: 316.37484
MOL File: 1246819-50-0.mol

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Febuxostat-d9 Property

Melting point:: >201°C (dec.)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25033
Product name: Febuxostat-d9
Purity: ≥99% deuterated forms (d1-d9)
Packaging: 1mg
Price: $261
Updated: 2024/03/01

TRC

Product number: F229002
Product name: Febuxostat-d9
Packaging: 1mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 3669AH
Product name: Febuxostat-D9
Packaging: 1mg
Price: $471
Updated: 2021/12/16

aablocks

Product number: AA009CF5
Product name: Febuxostat-d9
Purity: ≥99%deuteratedforms(d<sub>1</sub>-d<sub>9</sub>)
Packaging: 1mg
Price: $394
Updated: 2021/12/16

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Febuxostat-d9 Chemical Properties,Usage,Production

Description

Febuxostat-d₉ is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC₅₀s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; K_is = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED₅₀ = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.

Uses

Febuxostat-d9 is a Labeled compound, intended for use as an internal standard for the quantification of Febuxostat by GC- or LC-mass spectrometry.

Uses

Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.

References

[1] KEN OKAMOTO. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition.[J]. The Journal of Biological Chemistry, 2003, 278 3: 1848-1855. DOI: 10.1074/jbc.m208307200
[2] YOSHIO OSADA. Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents[J]. European journal of pharmacology, 1993, 241 2: Pages 183-188. DOI: 10.1016/0014-2999(93)90201-r
[3] YASUHIRO TAKANO . Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase[J]. Life sciences, 2005, 76 16: Pages 1835-1847. DOI: 10.1016/j.lfs.2004.10.031
[4] MANISHA BISHT S S B. Febuxostat: a novel agent for management of hyperuricemia in gout.[J]. Indian Journal of Pharmaceutical Sciences, 2011, 73 6: 597-600. DOI: 10.4103/0250-474x.100231
[5] YUSUKE NAKATSU. The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2015: G42-51. DOI: 10.1152/ajpgi.00443.2014
[6] JOSEPHE A HONORAT. Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.[J]. PLoS ONE, 2017: e0187215. DOI: 10.1371/journal.pone.0187215

Febuxostat-d9 Preparation Products And Raw materials

Raw materials

Preparation Products

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1246819-50-0, Febuxostat-d9Related Search:

Febuxostat 2-HYDROXY-THIOBENZAMIDE 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Febuxostat impurity 37 FeBuxostat Impurity 33 3-Cyano-4-isobutoxybenzoic acid ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 4-ISOBUTOXY-BENZALDEHYDE 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 6 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Impurity 8 Febuxostat Impurity 14 Febuxostat Bromo Impurity

Febuxostat-d9

2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid

2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

TEI 6720-d9

TMX 67-d9

[2H9]-Febuxostat

Febuxostat-d9 (2-methylpropoxy-d9)

Febuxostat D9Q: What is Febuxostat D9 Q: What is the CAS Number of Febuxostat D9 Q: What is the storage condition of Febuxostat D9 Q: What are the applications of Febuxostat D9

Febuxostat-d

2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid

5-Thiazolecarboxylic acid, 2-[3-cyano-4-[2-(methyl-d3)propoxy-1,1,2,3,3,3-d6]phenyl]-4-methyl-

Dapagliflozin Impurity 138

D9-Febuxostat

1246819-50-0

C16H7D9N2O3S

Inhibitors

Intermediates & Fine Chemicals

Isotope Labelled Compounds

Pharmaceuticals

Heterocycles