ChemicalBook > CAS DataBase List > Febuxostat-d9

Febuxostat-d9

Product Name
Febuxostat-d9
CAS No.
1246819-50-0
Chemical Name
Febuxostat-d9
Synonyms
TMX 67-d9;TEI 6720-d9;Febuxostat-d;Febuxostat-d9;[2H9]-Febuxostat;Dapagliflozin Impurity 138;Febuxostat-d9 (2-methylpropoxy-d9);2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid;2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid;2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid
CBNumber
CB22508843
Molecular Formula
C16H16N2O3S
Formula Weight
316.37484
MOL File
1246819-50-0.mol
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Febuxostat-d9 Property

Melting point:
>201°C (dec.)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25033
Product name
Febuxostat-d9
Purity
≥99% deuterated forms (d1-d9)
Packaging
1mg
Price
$261
Updated
2024/03/01
TRC
Product number
F229002
Product name
Febuxostat-d9
Packaging
1mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
3669AH
Product name
Febuxostat-D9
Packaging
1mg
Price
$471
Updated
2021/12/16
aablocks
Product number
AA009CF5
Product name
Febuxostat-d9
Purity
≥99%deuteratedforms(d<sub>1</sub>-d<sub>9</sub>)
Packaging
1mg
Price
$394
Updated
2021/12/16
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Febuxostat-d9 Chemical Properties,Usage,Production

Description

Febuxostat-d9 is intended for use as an internal standard for the quantification of febuxostat by GC- or LC-MS. Febuxostat is an antihyperuricemic nonpurine inhibitor of both the oxidized and reduced forms of xanthine oxidase. It inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively). It is 10-30 times more potent than the hypoxanthine analog allopurinol (; Kis = 0.7 nM and 0.7 μM, respectively). Febuxostat decreases the serum level of urate in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg). It reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids when administered at a dose of 1 mg/kg per day. Febuxostat (0.75 mg/kg) also increases CNS expression of glutamate oxaloacetate transaminase 2 (GOT2) and improves neurological symptoms in a mouse model of secondary progressive experimental autoimmune encephalomyelitis (EAE). Formulations containing febuxostat have been used in the treatment of symptomatic hyperuricemia in patients with gout.

Uses

Febuxostat-d9 is a Labeled compound, intended for use as an internal standard for the quantification of Febuxostat by GC- or LC-mass spectrometry.

Uses

Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.

Febuxostat-d9 Preparation Products And Raw materials

Raw materials

Preparation Products

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1246819-50-0, Febuxostat-d9Related Search:

Febuxostat 2-HYDROXY-THIOBENZAMIDE 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Febuxostat impurity 37 FeBuxostat Impurity 33 3-Cyano-4-isobutoxybenzoic acid ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 4-ISOBUTOXY-BENZALDEHYDE 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 6 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Impurity 8 Febuxostat Impurity 14 Febuxostat Bromo Impurity

  • Febuxostat-d9
  • 2-(3-Cyano-4-isobutyloxyphenyl-d9)-4-Methyl-5-thiazolecarboxylic Acid
  • 2-[3-Cyano-4-(2-Methylpropoxy-d9)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
  • TEI 6720-d9
  • TMX 67-d9
  • [2H9]-Febuxostat
  • Febuxostat-d9 (2-methylpropoxy-d9)
  • Febuxostat D9Q: What is Febuxostat D9 Q: What is the CAS Number of Febuxostat D9 Q: What is the storage condition of Febuxostat D9 Q: What are the applications of Febuxostat D9
  • Dapagliflozin Impurity 138
  • Febuxostat-d
  • 2-(3-Cyano-4-(2-(methyl-d3)propoxy-1,1,2,3,3,3-d6)phenyl)-4-methylthiazole-5-carboxylic acid
  • 5-Thiazolecarboxylic acid, 2-[3-cyano-4-[2-(methyl-d3)propoxy-1,1,2,3,3,3-d6]phenyl]-4-methyl-
  • 1246819-50-0
  • C16H7D9N2O3S
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals
  • Heterocycles