LDN-193189

ChemicalBook > CAS DataBase List > LDN-193189

Product Name: LDN-193189
CAS No.: 1062368-24-4
Chemical Name: LDN-193189
Synonyms: LDN193189;CS-205;DM-3189;DM 3189;LDN193189(DM3189);LDN-193189, >=98%;LDN193189 free base;LDN-193189;LDN 193189;LDN193189 LDN193189 HCl;LDN-193189;LDN 193189;DM-3189;DM 3189
CBNumber: CB22512071
Molecular Formula: C25H22N6
Formula Weight: 406.48
MOL File: 1062368-24-4.mol

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LDN-193189 Property

Density: 1.33
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: H2O: soluble5mg/mL, clear (warmed)
form: powder
pka: 8.79±0.10(Predicted)
color: yellow to orange
InChIKey: XHBVYDAKJHETMP-UHFFFAOYSA-N

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Safety

WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0559
Product name: LDN193189 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0559
Product name: LDN193189 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $522
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 1mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 10mg
Price: $140
Updated: 2024/03/01

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LDN-193189 Chemical Properties,Usage,Production

Description

Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC₅₀ value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC₅₀s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC₅₀s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases. Potent BMP Inhibitor?, Promotes hPSC Neural Induction?.

Definition

ChEBI: 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline is a member of pyrimidines.

Biochem/physiol Actions

Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LDN-193189 manufacturers

Career Henan Chemical Co

Product: 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine 1062368-24-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1062368-24-4, LDN-193189Related Search:

LDN-212320 LDN-193189 HCl 2,5-Dimethoxyaniline tert-Butyl 1-piperazinecarboxylate Piperazine LDN-214117 Y27632 (hydrochloride) 1,9-Pyrazoloanthrone SB 431542 LY2109761 ICG-001 LDN212854 Ldn193189

LDN193189 LDN193189 HCl

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

LDN-193189;LDN 193189;DM-3189;DM 3189

LDN-193189;LDN 193189

CS-205

LDN193189 free base

LDN193189(DM3189)

LDN193189

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

DM 3189

DM-3189

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189)

4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline LDN 193189

LDN 193189 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride

LDN-193189, >=98%

LDN-193189, 98%, a selective BMP signaling inhibitor

Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine USP/EP/BP

1062368-24-4

C25H22N6

Smad

TGF-beta

Inhibitors

TGF-beta/Smad