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PF-4708671

Product Name
PF-4708671
CAS No.
1255517-76-0
Chemical Name
PF-4708671
Synonyms
CS-869;PF 4708671;PF-04708671;PF4708671/PF-4708671;PF-4708671 USP/EP/BP;PF 4708671 - PF 04708671;PF-4708671 PF4708671 S6 kinase inhibitor;2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole;2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole;1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
CBNumber
CB22518730
Molecular Formula
C19H21F3N6
Formula Weight
390.41
MOL File
1255517-76-0.mol
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PF-4708671 Property

Boiling point:
572.8±50.0 °C(Predicted)
Density 
1.348±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
pka
10.20±0.10(Predicted)
form 
powder
color 
off-white
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0143
Product name
PF-4708671
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0143
Product name
PF-4708671
Purity
≥98% (HPLC)
Packaging
25mg
Price
$545
Updated
2024/03/01
Cayman Chemical
Product number
15018
Product name
PF-04708671
Purity
≥98%
Packaging
10mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
15018
Product name
PF-04708671
Purity
≥98%
Packaging
25mg
Price
$218
Updated
2024/03/01
Cayman Chemical
Product number
15018
Product name
PF-04708671
Purity
≥98%
Packaging
50mg
Price
$412
Updated
2024/03/01
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PF-4708671 Chemical Properties,Usage,Production

Chemical Properties

Pale purple Solid

Uses

PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

Biological Activity

pf-4708671 is a cell-permeable and highly specific inhibitor of p70 ribosomal s6 kinase 1 with ic50 value of 160nm [1].s6k1 is a regulator of various biology processes. the inhibition of s6k1 is regard as a therapeutic for the treatment of cancer and insulin resistance. pf-4708671 is the first reported inhibitor of s6k1. it inhibits the activity of s6k1 in the in vitro assay with ki value of 20nm. for the isolated s6k1 from hek293 cell, pf-4708671 shows inhibition with ic50 value of 160nm. the inhibition of s6k1caused by pf-4708671 is much more potent than of other related kinases such as rsk2 and msk1. besides that, pf-4708671 prevents s6k1 from phosphorylating its substrates including the ribosomal s6 protein, mtor and rictor. in addition, pf-4708671 is found to enhance the phosphorylation of s6k1 at thr229 and thr389, results in a subsequent increase of s6k1 activity. whereas this increased activity is much less than that stimulated by igf1 [1].

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Enzyme inhibitor

This cell-permeable protein kinase inhibitor (FW = 390.41 g/mol; CAS 1255517-76-0; Solubility = 30 mg/mL DMSO, <1 mg/mL H2O) targets p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM, without significant inhibition of S6K2 isoform or Akt1, Akt2, PKA, PKCα, PKC?, PRK2, ROCK2, RSK1, RSK2, or SGK1. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMAinduced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

storage

Store at +4°C

References

[1] pearce l, alton g, richter d, et al. characterization of pf-4708671, a novel and highly specific inhibitor of p70 ribosomal s6 kinase (s6k1). biochem. j, 2010, 431: 245-255.

PF-4708671 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-4708671 Suppliers

Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from PF-4708671 manufacturers

Career Henan Chemical Co
Product
2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole 1255517-76-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-23

1255517-76-0, PF-4708671Related Search:


  • 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
  • PF 4708671
  • PF4708671/PF-4708671
  • 2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole
  • PF-04708671
  • 2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
  • 1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
  • 2-[[4-(5-Ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole PF-4708671
  • CS-869
  • PF 4708671 - PF 04708671
  • PF-4708671 USP/EP/BP
  • 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
  • PF-4708671 PF4708671 S6 kinase inhibitor
  • 1255517-76-0
  • C19H21F3N6
  • API
  • Akt
  • mTOR
  • PI3K
  • PI3K/Akt/mTOR
  • Amines
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals