ChemicalBook > CAS DataBase List > 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Product Name
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS No.
1134156-31-2
Chemical Name
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
Synonyms
CS-1647;VER 155088;VER 155008;HSP70 inhibitor;VER-155008, ≥98% (HPLC);VER 155008;VER-155008;VER155008;8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine;8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008;5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine;5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CBNumber
CB22518790
Molecular Formula
C25H23Cl2N7O4
Formula Weight
556.4
MOL File
1134156-31-2.mol
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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Property

Boiling point:
856.3±75.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
pka
13.04±0.70(Predicted)
form 
powder
color 
white to light brown
InChIKey
ZXGGCBQORXDVTE-UMCMBGNQSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0271
Product name
VER-155008
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0271
Product name
VER-155008
Purity
≥98% (HPLC)
Packaging
25mg
Price
$531
Updated
2024/03/01
Cayman Chemical
Product number
17257
Product name
VER-155008
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17257
Product name
VER-155008
Purity
≥95%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
17257
Product name
VER-155008
Purity
≥95%
Packaging
25mg
Price
$388
Updated
2024/03/01
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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Chemical Properties,Usage,Production

Uses

VER 155008 is a novel adenosine-derived inhibitor of heat-shocked protein 70, Hsp70 resulting in an inhibition of cell proliferation of human cancer cell lines.

Uses

VER-155008 has been used as a heat shock protein 70 (HSP70) inhibitor:

  • to study its effects on human embryonic kidney 293 (HEK293T)?cells
  • to study its effects on viral mRNA synthesis and protein expression in Vero E6 cells
  • to determine its effects on the attenuation of seizures in rats

Definition

ChEBI: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]-9-purinyl]-3,4-dihydroxy-2-oxolanyl]methoxymethyl]benzonitrile is a purine nucleoside.

Biological Activity

ver 155008 is a potent inhibitor of heat shock protein 70 (hsp70) family of chaperones, which have been shown to contribute to cancer cell survival via anti-apoptotic functions, that inhibits hsp70 (with the value of 50% inhibition concentration ic50 of 0.5 μm) as well as heat shock cognate 71 kda protein (hsc70) and 78 kda glucose-regulated protein (grp78) but to a lesser extent. x-ray crystallography analysis reveals that ver 155008 binds to the atpase pocket of hsp70 leading to the inhibition of the intrinsic atpase activity of hsp70. study results also have demonstrated that ver 155008 induces cell proliferation and apoptosis in human cancer cell lines.massey aj, williamson ds, browne h, murray jb, dokurno p, shaw t, macias at, daniels z, geoffroy s, dopson m, lavan p, matassova n, francis gl, graham cj, parsons r, wang y, padfield a, comer m, drysdale mj, wood m. a novel, small molecule inhibitor of hsc70/hsp70 potentiates hsp90 inhibitor induced apoptosis in hct116 colon carcinoma cells. cancer chemother pharmacol. 2010; 66(3): 535-545

Biochem/physiol Actions

VER‐155008 positively promotes memory recovery and axonal regrowth. It is also involved in inhibiting cell cycle progression and proliferation in non-small-cell lung cancer (NSCLC).

storage

Desiccate at RT

5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine Suppliers

China 84 India 2 The Netherlands 1 United Kingdom 1 United States 19 Global 107
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine manufacturers

Career Henan Chemical Co
Product
5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine 1134156-31-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-22

1134156-31-2, 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosineRelated Search:

VER-246608 VER-50589 VER-49009

  • VER 155008
  • 4-((((2R,3S,4R,5R)-5-(6-aMino-8-((3,4-dichlorobenzyl)aMino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)benzonitrile
  • 8-(3,4-Dichlorobenzyl)aMino-5'-O-(4-cyanobenzyl)adenosine
  • 4-{(2R,3S,4R,5R)-5-[6-aMino-8-(3,4-dichlorobenzylaMino)purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-ylMethoxyMethyl}benzonitrile
  • VER 155088
  • CS-1647
  • VER 155008;VER-155008;VER155008
  • 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
  • HSP70 inhibitor
  • Adenosine, 5'-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-
  • 8-(3,4-Dichlorobenzyl)amino-5’-O-(4-cyanobenzyl)adenosine, VER155008
  • VER-155008, ≥98% (HPLC)
  • 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
  • 1134156-31-2
  • C25H23Cl2N7O4