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AT7867

Product Name
AT7867
CAS No.
857531-00-1
Chemical Name
AT7867
Synonyms
AT7867;CS-1865;AT-7867(AT7867);AT7867 USP/EP/BP;AT7867, 10 mM in DMSO;4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-;4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine AT 7867;Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]- 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
CBNumber
CB22526153
Molecular Formula
C20H20ClN3
Formula Weight
337.85
MOL File
857531-00-1.mol
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AT7867 Property

Density 
1.214
storage temp. 
Store at -20°C
solubility 
≥16.9 mg/mL in DMSO; ≥4.38 mg/mL in EtOH with ultrasonic; ≥45 mg/mL in H2O
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16848
Product name
AT7867
Purity
≥98%
Packaging
25mg
Price
$414
Updated
2024/03/01
Cayman Chemical
Product number
16848
Product name
AT7867
Purity
≥98%
Packaging
500μg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
16848
Product name
AT7867
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2021/12/16
Cayman Chemical
Product number
16848
Product name
AT7867
Purity
≥98%
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
16848
Product name
AT7867
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
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AT7867 Chemical Properties,Usage,Production

Description

AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety of cancer cell lines in vitro and suppresses tumor growth of PTEN-deficient xenografts in mice.

Uses

A potent Akt inhibitor with an IC50 of 17 nM. AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50s of 20 nM and 85 nM, respectively.

Definition

ChEBI: AT7867 is a member of the class of piperidines carrying two aryl substituents (4-chlorophenyl and 4-(pyrazol-4-yl)phenyl) at position 4. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is a member of pyrazoles, a member of piperidines and a member of monochlorobenzenes.

Enzyme inhibitor

This potent ATP-competitive inhibitor (FW = 337.85; CAS 857531-00-1; Solubility: 68 mg/mL DMSO, <1 mg/mL H2O), known systematically as 4- (4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine, targets Akt1, Akt2 and Akt3 Protein Kinases B (or PKB), with IC50 values of 32 nM, 17 nM and 47 nM, respectively. AT7867 also inhibits the structurally related AGC kinases, p70S6K and PKA, with IC50 values of 20 nM and 85 nM, respectively.

target

Akt2

References

grimshaw km, hunter lj, yap ta et al. at7867 is a potent and oral inhibitor of akt and p70 s6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. mol cancer ther. 2010 may;9(5):1100-10.

AT7867 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT7867 Suppliers

China 84 United States 17 Global 101
MedChemexpress LLC
Tel
021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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info@adooq.com
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United States
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Target molecule Corp.
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857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
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United States
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
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sales@aladdinsci.com
Country
United States
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57505
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58
TargetMol Chemicals Inc.
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support@targetmol.com
Country
United States
ProdList
38631
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58
ApexBio Technology
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Alfa Chemistry
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Santa Cruz Biotechnology, Inc.
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Abcam
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Cayman Chemical Company
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cayman@caymanchem.com
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Creative Enzymes
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Matrix Scientific
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Selleck Chemicals LLC
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View Lastest Price from AT7867 manufacturers

Career Henan Chemical Co
Product
AT7867 857531-00-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

857531-00-1, AT7867Related Search:

AZD7762 Bosutinib (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PF-4708671 AZD5363 SCH772984

  • AT7867
  • Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-
  • 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
  • AT-7867(AT7867)
  • 4-(4-(1H-pyrazol-4-yl)phenyl)-4-(4-chlorophenyl)piperidine
  • 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine AT 7867
  • CS-1865
  • Piperidine, 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]- 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
  • AT7867 USP/EP/BP
  • AT7867, 10 mM in DMSO
  • 857531-00-1
  • Akt
  • mTOR
  • PI3K
  • Inhibitors