Bikinin

Product Name: Bikinin
CAS No.: 188011-69-0
Chemical Name: Bikinin
Synonyms: Bikinin;Abrasin;CS-1658;Bikinin, >98%;Bikinin(Abrasin);Bikinin USP/EP/BP;Bikinin - CAS 188011-69-0 - Calbiochem;4-[(5-Bromo-2-pyridyl)amino]-4-oxobutyric Acid;4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid;4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid
CBNumber: CB22537971
Molecular Formula: C9H9BrN2O3
Formula Weight: 273.08
MOL File: 188011-69-0.mol

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Bikinin Property

Melting point:: 144°C(lit.)
Boiling point:: 521.6±45.0 °C(Predicted)
Density: 1.711
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL
form: White solid
pka: 4.59±0.10(Predicted)
color: white to tan
InChIKey: XFYYQDHEDOXWGA-UHFFFAOYSA-N
CAS DataBase Reference: 188011-69-0

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933.39.9200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0094
Product name: Bikinin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $91.3
Updated: 2024/03/01

TCI Chemical

Product number: B4826
Product name: Bikinin
Purity: >98.0%(HPLC)(T)
Packaging: 25mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 18381
Product name: Bikinin
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 18381
Product name: Bikinin
Purity: ≥98%
Packaging: 10mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0094
Product name: Bikinin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $224.4
Updated: 2024/03/01

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Bikinin Chemical Properties,Usage,Production

Uses

Bikinin has been used:

as a glycogen synthase kinase-3 (GSK3) inhibitor in Arabidopsis Col-0 seedlings to test its effect on gene expression
as a component of induction medium and as a GSK3 inhibitor to test its effect on mesophyll cells in Arabidopsis leaf discs or cotyledons
as a brassinosteroid agonist to test its effect on the leaf index of R. trichophyllus terrestrial leaves

Biochem/physiol Actions

Bikinin is a strong activator of brassinosteroid (BR) signaling. It is an Arabidopsis GSK-3 Inhibitor, an Arabidopsis SHAGGY-related Kinase Inhibitor, and a GSK-3-like Kinase BIN2 Inhibitor. Bikinin directly inhibits BIN2 (group II GSK3s) by interfering with ATP binding. Bikinin is specific toward a subset of Arabidopsis GSK3 kinases including BIN2 and ASK α, γ, ε, ι, and θ.

Enzyme inhibitor

This ATP-competitive Arabidopsis GSK-3 inhibitor, (FW = 273.08 g/mol; CAS 188011-69-0), also named 4-(5-bromopyridin-2-ylamino)-4- oxobutanoic acid, is a strong activator of brassinosteroid (BR) signaling. Bikinin directly binds the GSK3 BIN2 and also inhibits the activity of six other Arabidopsis GSK3s. Genome-wide transcript analyses demonstrate that simultaneous inhibition of seven GSK3s is sufficient to activate BR responses. inhibited the SnRK2.3 kinase activity and its T180 phosphorylation in vivo by blocking BIN2 phosphorylation of SnRK2.3 on Thr-180.

Bikinin Preparation Products And Raw materials

Raw materials

Preparation Products

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Bikinin Suppliers

Americas 1 China 102 Europe 1 India 2 Japan 1 United Kingdom 1 United States 15 Global 123

Atomic chemistry

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Shanghai Boyle Chemical Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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ShangHai YuanYe Biotechnology Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Country: China
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TOKYO CHEMICAL INDUSTRY CO., LTD.

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TCI Europe

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Guangzhou Isun Pharmaceutical Co., Ltd

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TargetMol Chemicals Inc.

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View Lastest Price from Bikinin manufacturers

Career Henan Chemical Co

Product: Bikinin 188011-69-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

Career Henan Chemical Co

Product: Bikinin 188011-69-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

188011-69-0, BikininRelated Search:

Semagacestat DAPT Avagacestat (BMS-708163)

Butanoic acid, 4-[(5-bromo-2-pyridinyl)amino]-4-oxo-

Bikinin

4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid

4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid

Abrasin

Bikinin(Abrasin)

CS-1658

Bikinin, >98%

Bikinin - CAS 188011-69-0 - Calbiochem

4-[(5-Bromo-2-pyridyl)amino]-4-oxobutyric Acid

Bikinin USP/EP/BP

188011-69-0

188011-09-0

Inhibitors