1,8-Diaminooctane
- Product Name
- 1,8-Diaminooctane
- CAS No.
- 373-44-4
- Chemical Name
- 1,8-Diaminooctane
- Synonyms
- 1,8-OCTANEDIAMINE;Octane-1,8-diamine;Xin diaMine;8-Diaminooctane;1,8-Oktandiamin;1,8-diaMine Xin;FENTAMINE HP-82;1,8- Octylamine;1,4-Octanediamine;1,8-DIAMINOOCTANE
- CBNumber
- CB2254212
- Molecular Formula
- C8H20N2
- Formula Weight
- 144.26
- MOL File
- 373-44-4.mol
1,8-Diaminooctane Property
- Melting point:
- 50-52 °C(lit.)
- Boiling point:
- 225-226 °C(lit.)
- Density
- 0.98 g/mL at 20 °C
- vapor pressure
- <0.1 hPa (20 °C)
- refractive index
- 1.4618 (estimate)
- Flash point:
- 329 °F
- storage temp.
- Store below +30°C.
- solubility
- 575g/l
- form
- Solidified Crystalline Mass
- pka
- 11.00, 10.1(at 20℃)
- color
- White to yellow
- PH
- 11.7 (4g/l, H2O, 20℃)
- explosive limit
- 1.1-6.8%(V)
- Water Solubility
- 575 g/L (20 ºC)
- Sensitive
- Hygroscopic
- BRN
- 1735426
- InChIKey
- PWGJDPKCLMLPJW-UHFFFAOYSA-N
- LogP
- 0.896 at 25℃
- CAS DataBase Reference
- 373-44-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,8-Diaminooctane(373-44-4)
- EPA Substance Registry System
- 1,8-Octanediamine (373-44-4)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39-45-37/39
- RIDADR
- UN 3259 8/PG 3
- WGK Germany
- 3
- RTECS
- RG8841500
- F
- 3-9-23
- Autoignition Temperature
- 280 °C DIN 51794
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29212900
- Toxicity
- LD50 orally in Rabbit: 500 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D22401
- Product name
- 1,8-Diaminooctane
- Purity
- 98%
- Packaging
- 25g
- Price
- $48.4
- Updated
- 2025/07/31
- Product number
- D22401
- Product name
- 1,8-Diaminooctane
- Purity
- 98%
- Packaging
- 100g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- D0107
- Product name
- 1,8-Diaminooctane
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- D0107
- Product name
- 1,8-Diaminooctane
- Purity
- >98.0%(GC)(T)
- Packaging
- 100g
- Price
- $82
- Updated
- 2025/07/31
- Product number
- D494060
- Product name
- 1,8-Diaminooctane
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
1,8-Diaminooctane Chemical Properties,Usage,Production
Chemical Properties
white to yellowish solidified crystalline mass
Uses
1,8-Diaminooctane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Definition
ChEBI: 1,8-diaminooctane is an alkane-alpha,omega-diamine in which the two amino groups are separated by eight methylene groups. It derives from a hydride of an octane.
Flammability and Explosibility
Non flammable
Safety Profile
Moderately toxic by ingestion. Asevere skin and eye irritant. When heated todecomposition it emits toxic vapors of NOx.
Synthesis
629-40-3
373-44-4
The general procedure for the synthesis of 1,8-octanediamine from 1,6-dicyanohexane was as follows: a 500 mL autoclave was assembled with a thermocouple thermometer, a stirrer (two-piece tilting paddle), a pressure gauge, and a hydrogen purge line. To the autoclave were added 175 g of 1,6-dicyanohexane, 86.0 g of methanol, 2.0 g of 28% sodium methacrylate-methanol solution (0.64% w/w), and 10.5 g of nickel catalyst (based on nickel monomers, which accounted for 6.0 w/w% of 1,6-dicyanohexane). The water content of the solution was 920 ppm at this point, as measured by a Karl Fischer hydrometer (manufactured by Hiranuma Sangyo Co., Ltd.) Upon completion of the dosing, hydrogen substitution was performed, and then the pressure was increased to 5 MPa. The temperature was raised to an internal temperature of 90 °C, and the ramping process lasted for approximately 1 hour. Hydrogen consumption was observed from about 70°C. The reaction was started at 90°C and hydrogen consumption essentially stopped after about 6 hours. After continuing the reaction for 2 hours, the reaction was cooled to room temperature, depressurized, and the reaction solution was filtered to remove the catalyst and the filtrate was washed with 100 g of methanol. The total weight of the 1,8-diaminooctane methanol reaction solution obtained was 377.4 g. The area of 1,8-diaminooctane was analyzed by GC to be 94.3% and the reaction yield was 96.7%.
Purification Methods
Distil the diamine under vacuum in an inert atmosphere (N2 or Ar), cool and store the distillate in an inert atmosphere in the dark. The dihydrochloride has m 273-274o. [Nae & Le Helv Chim Acta 15 55 1955, Beilstein 4 III 612.]
References
[1] Patent: JP2017/31143, 2017, A. Location in patent: Paragraph 0082; 0083; 0086; 0087
[2] Chemische Berichte, 1913, vol. 46, p. 230
[3] Patent: US6376714, 2002, B1
[4] Patent: US6376714, 2002, B1
[5] Patent: US2011/313186, 2011, A1. Location in patent: Page/Page column 11
1,8-Diaminooctane Preparation Products And Raw materials
Raw materials
Preparation Products
1,8-Diaminooctane Suppliers
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View Lastest Price from 1,8-Diaminooctane manufacturers
- Product
- 1,8-Diaminooctane 373-44-4
- Price
- US $0.00/kg
- Min. Order
- 800kg
- Purity
- 99%
- Supply Ability
- 35 ton/month
- Release date
- 2025-08-22
- Product
- 1,8-Diaminooctane 373-44-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2025-04-23
- Product
- 1,8-Diaminooctane 373-44-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28