16α-Methyl-11-oxo Prednisolone

Product Name: 16α-Methyl-11-oxo Prednisolone
CAS No.: 2036-77-3
Chemical Name: 16α-Methyl-11-oxo Prednisolone
Synonyms: DMS-0;Dexamethasone imp J;Carbamazepine Impurity 26;(8S,9S,10R,13S,14S,16R,17R);Dexamethasone EP Impurity J;16α-Methyl-11-oxo Prednisolone;16Alpha-Methyl-11-oxo Prednisolone;Tobramycin and dexamethasone impurity J;Dexamethasone impurity 4/Dexamethasone EP Impurity J;Dexamethasone Impurity 10(Dexamethasone EP Impurity J)
CBNumber: CB22544463
Molecular Formula: C22H28O5
Formula Weight: 372.45
MOL File: 2036-77-3.mol

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16α-Methyl-11-oxo Prednisolone Property

Melting point:: 197-199°C
Boiling point:: 574.4±50.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 12.38±0.70(Predicted)
color: White to Off-White
Major Application: pharmaceutical small molecule

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M295350
Product name: 16α-Methyl-11-oxoPrednisolone
Packaging: 25mg
Price: $850
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0005877
Product name: 16-ALPHA-METHYL-11-OXO PREDNISOLONE
Purity: 95.00%
Packaging: 5MG
Price: $496.54
Updated: 2021/12/16

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16α-Methyl-11-oxo Prednisolone Chemical Properties,Usage,Production

Uses

A 16α-substituted Prednisolone as potent topical antiinflammatory agent.

Synthesis

1) Add 5.0 g of pregnane-1,4,16-triene-3,11,20-trione (compound (I-1)) with 0.02 times copper bromide dimethyl sulfide, 1.2 times trimethylchlorosilane, 2 times hexamethylphosphorotriamine to 60 ml of tetrahydrofuran, and slowly add 1.2 times methylmagnesium bromide dissolved in the tetrahydrofuran to carry out the Grignard reaction, the temperature of the reaction is -30??-20??. The reaction was protected by passing N2, and at the end of the reaction it was diluted with water, separated and dried to obtain the Grignard product (compound (II-1)); 2) React the above Grignard with 3 times potassium bicarbonate and 1.5 times m-chloroperoxybenzoic acid in dichloromethane at a reaction temperature of -30 to -25??C, and react until complete. The solution pH was adjusted to 1 with hydrochloric acid, concentrated under reduced pressure, cooled, separated and dried to obtain the compound dexamethasone EP impurity J(III-1), total yield 78.2%.

16α-Methyl-11-oxo Prednisolone Preparation Products And Raw materials

Raw materials

Preparation Products

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16α-Methyl-11-oxo Prednisolone Suppliers

Canada 1 China 55 India 7 United States 4 Global 67

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2036-77-3, 16α-Methyl-11-oxo PrednisoloneRelated Search:

Dexamethasone 21-phosphate disodium salt Dexamethasone 21-Propionate PSXDNQUHAFMVPT-NWQAGDSVSA-N Dexamethasone 9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate 17β-Carboxy-17-desoxy Dexamethasone Dexamethasone-17-acetate 17-OXODEXAMETHASONE Betamethasone 1,2-Dihydro Dexamethasone 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate Dexamethasone 17-propionate 6-hydroxydexamethasone Dexamethasone palmitate 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate) 16-beta Methyl Epoxide (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione 17,21-dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione

Dexamethasone EP Impurity J

16α-Methyl-11-oxo Prednisolone

Dexamethasone Impurity 10(Dexamethasone EP Impurity J)

(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

(8S,9S,10R,13S,14S,16R,17R)

Dexamethasone impurity 4/Dexamethasone EP Impurity J

Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16α)-

(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione

17,21-dihydroxy-16α-methylpregna-1,4-diene-3,11,20-trione

Dexamethasone imp J

DMS-0

Carbamazepine Impurity 26

Tobramycin and dexamethasone impurity J

Dexamethasone EP Impurity J (9-desfluoro-11-keto dexamethasone )

17,21-Dihydroxy-16alpha-methylpregna-1,4-diene-3,11,20-trione

(8S,9S,10R,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione (Dexamethasone Impurity）

16Alpha-Methyl-11-oxo Prednisolone

2036-77-3

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