ChemicalBook > CAS DataBase List > MK8245

MK8245

Product Name
MK8245
CAS No.
1030612-90-8
Chemical Name
MK8245
Synonyms
CS-1662;]-5-isoxazoL;]-2H-tetrazoL;MK 8245;MK8245;e-2-acetic acid;MK8245 USP/EP/BP;5-[3-[4-(2-Bromo-5-fL;MK8245;MK-8245;MK 8245;uorophenoxy)-1-piperidinyL;5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
CBNumber
CB22546432
Molecular Formula
C17H16BrFN6O4
Formula Weight
467.25
MOL File
1030612-90-8.mol
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MK8245 Property

Boiling point:
698.3±65.0 °C(Predicted)
Density 
1.82
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form 
solid
pka
2.85±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H242Heating may cause a fire

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P234Keep only in original container.

P235Keep cool.

P240Ground/bond container and receiving equipment.

P370+P378In case of fire: Use … for extinction.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901744
Product name
2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
Packaging
100MG
Price
$114
Updated
2023/06/20
Cayman Chemical
Product number
29421
Product name
MK-8245
Packaging
1mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
29421
Product name
MK-8245
Packaging
25mg
Price
$836
Updated
2024/03/01
Cayman Chemical
Product number
29421
Product name
MK-8245
Packaging
5mg
Price
$268
Updated
2024/03/01
Cayman Chemical
Product number
29421
Product name
MK-8245
Packaging
10mg
Price
$435
Updated
2024/03/01
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MK8245 Chemical Properties,Usage,Production

Description

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).

Uses

This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

target

SCD1 (human)

References

[1] oballa rm, belair l, black wc, bleasby k, chan cc, desroches c, du x, gordon r, guay j, guiral s, hafey mj, hamelin e, huang z, kennedy b, lachance n, landry f, li cs, mancini j, normandin d, pocai a, powell da, ramtohul yk, skorey k, srensen d, sturkenboom w, styhler a, waddleton dm, wang h, wong s, xu l, zhang l. development of a liver-targeted stearoyl-coa desaturase (scd) inhibitor (mk-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. j med chem. 2011 jul 28;54(14):5082-96.
[2] lachance n, guiral s, huang z, leclerc jp, li cs, oballa rm, ramtohul yk, wang h, wu j, zhang l. discovery of potent and liver-selective stearoyl-coa desaturase (scd) inhibitors in an acyclic linker series. bioorg med chem lett. 2012 jan 1;22(1):623-7.

MK8245 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK8245 Suppliers

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View Lastest Price from MK8245 manufacturers

Career Henan Chemical Co
Product
MK8245 1030612-90-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-16

1030612-90-8, MK8245Related Search:

PI-103 Conivaptan hydrochloride ABT-199 MG-132 Olaparib Canertinib

  • MK 8245;MK8245
  • 5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
  • 2-(5-(3-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid
  • MK8245;MK-8245;MK 8245
  • CS-1662
  • ]-2H-tetrazoL
  • ]-5-isoxazoL
  • 5-[3-[4-(2-Bromo-5-fL
  • e-2-acetic acid
  • uorophenoxy)-1-piperidinyL
  • 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-
  • MK8245 USP/EP/BP
  • 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]aceticaci
  • 1030612-90-8
  • C17H16BrFN6O4
  • Inhibitors
  • Inhibitor