2-Fluoro-6-nitro-N-phenylbenzamide

Product Name: 2-Fluoro-6-nitro-N-phenylbenzamide
CAS No.: 870281-83-7
Chemical Name: 2-Fluoro-6-nitro-N-phenylbenzamide
Synonyms: Diethylcarbamazine Citrate-d3;2-Fluoro-6-nitro-N-phenylbenzamide;2- Fluoro-6-Nitro-N-Phenylbenzoamide;Benzamide, 2-fluoro-6-nitro-N-phenyl-
CBNumber: CB22555807
Molecular Formula: C13H9FN2O3
Formula Weight: 260.22
MOL File: 870281-83-7.mol

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2-Fluoro-6-nitro-N-phenylbenzamide Property

Melting point:: 163-165℃
Boiling point:: 342.4±32.0 °C(Predicted)
Density: 1.411±0.06 g/cm3 (20℃ 760 Torr)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 11.57±0.70(Predicted)
CAS DataBase Reference: 870281-83-7

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000057
Product name: 2-Fluoro-6-nitro-<I>N</I>-phenylbenzamide
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $103
Updated: 2025/07/31

Sigma-Aldrich

Product number: MNO000057
Product name: 2-Fluoro-6-nitro-N-phenylbenzamide
Purity: AldrichCPR
Packaging: 1G
Price: $99.7
Updated: 2024/03/01

TRC

Product number: F596439
Product name: 2-Fluoro-6-nitro-N-phenylbenzamide
Packaging: 1g
Price: $125
Updated: 2021/12/16

TRC

Product number: F596439
Product name: 2-Fluoro-6-nitro-N-phenylbenzamide
Packaging: 2.5g
Price: $260
Updated: 2021/12/16

TRC

Product number: F596439
Product name: 2-Fluoro-6-nitro-N-phenylbenzamide
Packaging: 250mg
Price: $45
Updated: 2021/12/16

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2-Fluoro-6-nitro-N-phenylbenzamide Chemical Properties,Usage,Production

Uses

2-Fluoro-6-nitro-N-phenylbenzamide is an intermediate used in the synthesis of an antitumor agent Idelalisib I.

Synthesis

385-02-4

62-53-3

870281-83-7

1. In a 100 mL reaction flask, 2-fluoro-6-nitrobenzoic acid (9.25 g, 0.05 mol) and carbonyldiimidazole (CDI) (8.9 g, 0.055 mol) were dissolved in 60 mL of DMF, and the reaction was stirred for 1 hr at 25 °C. Subsequently, aniline (5.6 g, 0.06 mol) was added to the reaction system and the reaction continued to be stirred at 25 °C for 5 hours. After completion of the reaction, the reaction solution was concentrated to dryness and extracted by adding 100 mL of water and 100 mL of dichloromethane to separate the organic phase. The dichloromethane layer was washed twice with water, and the combined organic layers were washed twice with saturated brine and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to afford 2-fluoro-6-nitro-N-phenylbenzamide (12.9 g) in 98.5% yield and 98% purity.

References

[1] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0034; 0035; 0036
[2] Patent: CN106146352, 2016, A. Location in patent: Paragraph 0024; 0025
[3] Patent: CN106146411, 2016, A. Location in patent: Paragraph 0023; 0024; 0025
[4] Patent: WO2016/108206, 2016, A2. Location in patent: Page/Page column 46
[5] Patent: EP3101020, 2016, A1. Location in patent: Paragraph 0084; 0085

2-Fluoro-6-nitro-N-phenylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-6-nitro-N-phenylbenzamide Suppliers

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View Lastest Price from 2-Fluoro-6-nitro-N-phenylbenzamide manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoro-6-nitro-N-phenylbenzamide 870281-83-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-fluoro-6-nitro-n-phenylbenzamide 870281-83-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-fluoro-6-nitro-n-phenylbenzamide 870281-83-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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870281-83-7