(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

Product Name: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
CAS No.: 870281-85-9
Chemical Name: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
Synonyms: CAL-101(N-2);idelalisib N-2;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2...;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate;tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate;(S)-[1-(5-FLUORO-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step);[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-,1,1-dimethylethyl ester;Carbamic acid, [(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-, 1,1-dimethylethyl ester (9CI)
CBNumber: CB32686182
Molecular Formula: C22H24FN3O3
Formula Weight: 397.44
MOL File: 870281-85-9.mol

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(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Property

Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.39±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809786
Product name: tert-Butyl(1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate
Packaging: 500mg
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: 9994AL
Product name: (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
Packaging: 5g
Price: $390
Updated: 2021/12/16

AK Scientific

Product number: 9994AL
Product name: (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
Packaging: 10g
Price: $594
Updated: 2021/12/16

AK Scientific

Product number: 9994AL
Product name: (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
Packaging: 1g
Price: $163
Updated: 2021/12/16

AK Scientific

Product number: 9994AL
Product name: (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
Packaging: 25g
Price: $1071
Updated: 2021/12/16

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(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Chemical Properties,Usage,Production

Uses

tert-Butyl (1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate is a reagent used in the discovery of a phosphoinositide 3-kinase (PI3K) b/d inhibitor for treatment of phosphatase and tensin homolog (PTEN) deficient tumors.

Synthesis

870281-84-8

870281-85-9

3. Preparation of tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate In a 200 mL reaction flask, compound (V) (8.9 g, 0.02 mol) was dissolved in 100 mL acetic acid and stirred until completely dissolved. Zinc powder (9.1 g, 0.14 mol) was added to the reaction system in batches, the reaction temperature was controlled at 25°C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction mixture was collected by vacuum filtration and the filter cake was washed with acetic acid (50 mL). The filtrate was concentrated and the filter cake was washed with dichloromethane (100 mL) and water (50 mL). Subsequently, the aqueous layer was extracted with dichloromethane (50 mL) and the organic phases were combined and washed sequentially with saturated sodium carbonate solution (50 mL) and saturated brine (50 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated to give the white solid compound (VI), i.e., tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate (6.2 g) in 78% yield and 95% purity.

References

[1] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0055; 0056; 0057; 0058
[2] Patent: WO2005/113554, 2005, A2. Location in patent: Page/Page column 24-25; 27-28
[3] Organic Preparations and Procedures International, 2016, vol. 48, # 4, p. 337 - 341
[4] Patent: WO2016/108206, 2016, A2. Location in patent: Page/Page column 47; 48
[5] RSC Advances, 2018, vol. 8, # 28, p. 15863 - 15869

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Suppliers

China 87 India 1 United Kingdom 1 United States 4 Global 93

ZhengZhou HuaWen Chemical Co.Ltd

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View Lastest Price from (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-04-28

Henan Aochuang Chemical Co.,Ltd.

Product: (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: MLN9708 870281-85-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

870281-85-9, (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMateRelated Search:

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(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step)

tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate, [(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester

idelalisib N-2

[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester

(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate

(S)-[1-(5-FLUORO-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER

Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-,1,1-dimethylethyl ester

CAL-101(N-2)

Carbamic acid, [(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-, 1,1-dimethylethyl ester (9CI)

Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2...

870281-85-9