(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Product Name
- (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- CAS No.
- 870281-85-9
- Chemical Name
- (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Synonyms
- CAL-101(N-2);idelalisib N-2;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2...;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate;tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate;(S)-[1-(5-FLUORO-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YL)-PROPYL]-CARBAMIC ACID TERT-BUTYL ESTER;(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate(CAL101 N-2 step);[(1S)-1-(5-Fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid,[(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-,1,1-dimethylethyl ester;Carbamic acid, [(1S)-1-(5-fluoro-3,4-dihydro-4-oxo-3-phenyl-2-quinazolinyl)propyl]-, 1,1-dimethylethyl ester (9CI)
- CBNumber
- CB32686182
- Molecular Formula
- C22H24FN3O3
- Formula Weight
- 397.44
- MOL File
- 870281-85-9.mol
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Property
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.39±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809786
- Product name
- tert-Butyl(1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 9994AL
- Product name
- (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Packaging
- 1g
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 9994AL
- Product name
- (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Packaging
- 5g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 9994AL
- Product name
- (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Packaging
- 10g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- 9994AL
- Product name
- (S)-tert-butyl(1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
- Packaging
- 25g
- Price
- $1071
- Updated
- 2021/12/16
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Chemical Properties,Usage,Production
Uses
tert-Butyl (1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2(1H)-ylidene)propyl)carbamate is a reagent used in the discovery of a phosphoinositide 3-kinase (PI3K) b/d inhibitor for treatment of phosphatase and tensin homolog (PTEN) deficient tumors.
Synthesis
870281-84-8
870281-85-9
3. Preparation of tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate In a 200 mL reaction flask, compound (V) (8.9 g, 0.02 mol) was dissolved in 100 mL acetic acid and stirred until completely dissolved. Zinc powder (9.1 g, 0.14 mol) was added to the reaction system in batches, the reaction temperature was controlled at 25°C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction mixture was collected by vacuum filtration and the filter cake was washed with acetic acid (50 mL). The filtrate was concentrated and the filter cake was washed with dichloromethane (100 mL) and water (50 mL). Subsequently, the aqueous layer was extracted with dichloromethane (50 mL) and the organic phases were combined and washed sequentially with saturated sodium carbonate solution (50 mL) and saturated brine (50 mL). The organic layer was dried with anhydrous magnesium sulfate and concentrated to give the white solid compound (VI), i.e., tert-butyl (S)-[1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]carbamate (6.2 g) in 78% yield and 95% purity.
References
[1] Patent: CN104130261, 2016, B. Location in patent: Paragraph 0055; 0056; 0057; 0058
[2] Patent: WO2005/113554, 2005, A2. Location in patent: Page/Page column 24-25; 27-28
[3] Organic Preparations and Procedures International, 2016, vol. 48, # 4, p. 337 - 341
[4] Patent: WO2016/108206, 2016, A2. Location in patent: Page/Page column 47; 48
[5] RSC Advances, 2018, vol. 8, # 28, p. 15863 - 15869
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate manufacturers
- Product
- (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-04-28
- Product
- (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 870281-85-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- MLN9708 870281-85-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-20