Amiodarone-D4 HCl

Product Name: Amiodarone-D4 HCl
CAS No.: 1216715-80-8
Chemical Name: Amiodarone-D4 HCl
Synonyms: Prosulfocarb Impurity 3-d10;Amiodarone hydrochloride salt;[2H4]-Amiodarone Hydrochloride;Amiodarone-D4 hydrochloride solution;Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
CBNumber: CB22560799
Molecular Formula: C25H30ClI2NO3
Formula Weight: 681.78
MOL File: 1216715-80-8.mol

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Amiodarone-D4 HCl Property

Flash point:: 9℃
storage temp.: -20°C
solubility: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
form: A solid
color: White to off-white
Stability:: Very Hygroscopic

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A-083
Product name: Amiodarone-D4 hydrochloride solution
Purity: 100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1ML
Price: $238
Updated: 2024/03/01

Cayman Chemical

Product number: 10010668
Product name: Amiodarone-d4 (hydrochloride)
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 1mg
Price: $194
Updated: 2024/03/01

Cayman Chemical

Product number: 10010668
Product name: Amiodarone-d4 (hydrochloride)
Purity: ≥99% deuterated forms (d1-d4)
Packaging: 5mg
Price: $724
Updated: 2024/03/01

TRC

Product number: A632952
Product name: Amiodarone-d4Hydrochloride
Packaging: 25mg
Price: $1390
Updated: 2021/12/16

TRC

Product number: A632952
Product name: Amiodarone-d4Hydrochloride
Packaging: 2.5mg
Price: $180
Updated: 2021/12/16

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Amiodarone-D4 HCl Chemical Properties,Usage,Production

Description

Amiodarone-d₄ is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC₅₀ value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ⁸Δ⁷ isomerase, and C-8 sterol isomerase (K_is = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC₅₀s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

Uses

A Labelled non-selective ion channel blocker. Antiarrhythmic (class III).

General Description

A Certified Spiking Solution^?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone^?, Cordarone^?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

Amiodarone-D4 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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Amiodarone-D4 HCl Suppliers

Canada 2 China 26 India 4 United States 5 Global 37

Sigma-Aldrich

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1216715-80-8, Amiodarone-D4 HClRelated Search:

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Amiodarone-D4 hydrochloride solution

(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride

AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)

[2H4]-Amiodarone Hydrochloride

Amiodarone hydrochloride salt

Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride

Prosulfocarb Impurity 3-d10

Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol

1216715-80-8