2-(6-broMopyridin-2-yl)propan-2-ol
Application- Product Name
- 2-(6-broMopyridin-2-yl)propan-2-ol
- CAS No.
- 638218-78-7
- Chemical Name
- 2-(6-broMopyridin-2-yl)propan-2-ol
- Synonyms
- 2-(6-bromopyridine) -2-propanol;2-(6-Bromo-2-pyridyl)-2-propanol;2-(6-broMopyridin-2-yl)propan-2-ol;2-Pyridinemethanol, 6-bromo-α,α-dimethyl-;2-(6-broMopyridin-2-yl)propan-2-ol ISO 9001：2015 REACH
- CBNumber
- CB22560971
- Molecular Formula
- C8H10BrNO
- Formula Weight
- 216.08
- MOL File
- 638218-78-7.mol
2-(6-broMopyridin-2-yl)propan-2-ol Property
- Boiling point:
- 273.2±25.0 °C(Predicted)
- Density
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.23±0.29(Predicted)
- Appearance
- Colorless to off-white Solid-liquid mixture
- InChI
- InChI=1S/C8H10BrNO/c1-8(2,11)6-4-3-5-7(9)10-6/h3-5,11H,1-2H3
- InChIKey
- OXSDDDKLMCHNHF-UHFFFAOYSA-N
- SMILES
- CC(C1=NC(Br)=CC=C1)(O)C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B429370
- Product name
- 2-(6-bromopyridin-2-yl)propan-2-ol
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB141391
- Product name
- 2-(6-Bromopyridin-2-yl)propan-2-ol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB141391
- Product name
- 2-(6-Bromopyridin-2-yl)propan-2-ol
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB141391
- Product name
- 2-(6-Bromopyridin-2-yl)propan-2-ol
- Packaging
- 500mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FB141391
- Product name
- 2-(6-Bromopyridin-2-yl)propan-2-ol
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
2-(6-broMopyridin-2-yl)propan-2-ol Chemical Properties,Usage,Production
Application
2-(6-bromopyridine)-2-propanol can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical production processes.
Synthesis
626-05-1
67-64-1
638218-78-7
GENERAL STEPS: In a dry 250 mL round-bottomed flask equipped with a stir bar, septum and temperature probe, 1.6 M hexane solution of n-butyllithium (31.2 mL, 50 mmol) was added. The reaction system was cooled to -76 °C in a dry ice-acetone bath. Subsequently, THF (30 mL) was added to the reaction vial and a solution of 2,6-dibromopyridine (11.5 g, 50 mmol) in THF (60 mL) was added slowly dropwise by syringe, controlling the reaction temperature below -60 °C. Stirring of the dark yellow-brown solution was continued in a dry ice bath for 30 min, and then acetone (6 mL, 80 mmol) was added. The reaction mixture was stirred in a dry ice bath for 15 minutes and then slowly warmed to room temperature. After 1 hour of reaction, the reaction was quenched by careful addition of 5% aqueous ammonium chloride solution (50 mL). The reaction mixture was extracted with dichloromethane, the organic phases were combined and the solvent evaporated to give 2-(6-bromopyridin-2-yl)propan-2-ol (10.6 g, 98% yield) as an orange oil. The mass spectrum (MS) showed m/z: 216 and 218 (M+H)+.
References
[1] Patent: WO2009/131814, 2009, A2. Location in patent: Page/Page column 40
[2] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0461; 0462
[3] Patent: WO2014/60371, 2014, A1. Location in patent: Page/Page column 76
[4] Chemical Communications, 2016, vol. 52, # 74, p. 11056 - 11059
[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 50
2-(6-broMopyridin-2-yl)propan-2-ol Preparation Products And Raw materials
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View Lastest Price from 2-(6-broMopyridin-2-yl)propan-2-ol manufacturers
- Product
- 2-(6-broMopyridin-2-yl)propan-2-ol 638218-78-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-24
- Product
- 2-(6-broMopyridin-2-yl)propan-2-ol 638218-78-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12
- Product
- 2-(6-broMopyridin-2-yl)propan-2-ol 638218-78-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18