2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Product Name: 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS No.: 1053228-29-7
Chemical Name: 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
Synonyms: 2,6-dichloro-7-fluoro-7-deaza-9H-purine;2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE;7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-5-fluoro-
CBNumber: CB22567309
Molecular Formula: C6H2Cl2FN3
Formula Weight: 206
MOL File: 1053228-29-7.mol

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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Property

Melting point:: 234 °C(Solv: dichloromethane (75-09-2))
Density: 1.769±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.82±0.50(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B419690
Product name: 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 100mg
Price: $330
Updated: 2021/12/16

Apolloscientific

Product number: PC201011
Product name: 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98%
Packaging: 100mg
Price: $174
Updated: 2021/12/16

Apolloscientific

Product number: PC201011
Product name: 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98%
Packaging: 250mg
Price: $277
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-7-2Z
Product name: 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 98%
Packaging: 100mg
Price: $279
Updated: 2021/12/16

AK Scientific

Product number: 1219AA
Product name: 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 100mg
Price: $305
Updated: 2021/12/16

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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

90213-66-4

1053228-29-7

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 1.06 mmol) was used as starting material and dissolved in acetonitrile (5.0 mL). Subsequently, 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octanebis(tetrafluoroborate) (561.6 mg, 1.6 mmol) and acetic acid (1 mL) were added sequentially to this solution. The reaction mixture was heated at 80 °C and stirred continuously for 24 hours. Upon completion of the reaction, the organic layer was separated, dried with anhydrous magnesium sulfate, filtered to remove the desiccant, and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford the target compound 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (170.0 mg, 80.1% yield). The product was confirmed by NMR hydrogen spectroscopy (500 MHz, CD3OD) with a chemical shift δ of 7.36 (s, 1H).

References

[1] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 91
[2] Patent: WO2017/87905, 2017, A1. Location in patent: Page/Page column 177
[3] Patent: WO2009/131687, 2009, A2. Location in patent: Page/Page column 129
[4] Patent: US2010/204221, 2010, A1. Location in patent: Page/Page column 18
[5] Patent: WO2012/151561, 2012, A1. Location in patent: Page/Page column 58

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Suppliers

China 54 India 1 United States 6 Global 61

PharmaBlock Sciences (Nanjing),Inc.

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View Lastest Price from 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers

Career Henan Chemical Co

Product: 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE 1053228-29-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2018-07-30

1053228-29-7, 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINERelated Search:

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-5-fluoro-

2,6-dichloro-7-fluoro-7-deaza-9H-purine

1053228-29-7

C6H2Cl2FN3