1H-Indole, 4-broMo-5-Methoxy-

1H-Indole, 4-broMo-5-Methoxy- Property

Boiling point:

349.2±22.0 °C(Predicted)

Density 

1.591±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

15.77±0.30(Predicted)

Appearance

White to yellow Solid

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

1H-Indole, 4-broMo-5-Methoxy- Chemical Properties,Usage,Production

Synthesis

Example 12 Synthesis of 4-bromo-5-methoxyindole (XLVI): to a solution of 2-bromo-4-nitroanisole (1.16 g, 5 mmol) in tetrahydrofuran (THF, 10 ml) was slowly added vinylmagnesium bromide (1 M solution in THF, 15 ml) at -40 °C. The reaction mixture was stirred at this temperature for 30 min, followed by a slow warming to -20 °C. Upon completion of the reaction, the reaction was quenched by the addition of saturated ammonium chloride (NH4Cl) solution and subsequently diluted with ether (Et2O). The aqueous layer was extracted twice with ether (Et2O). All organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Purification by fast chromatography (eluent: hexane/ethyl acetate) gave 4-bromo-5-methoxyindole (XLVI, 38 mg, 3% yield) as an oil.

References

[1] Patent: US2007/123527, 2007, A1. Location in patent: Page/Page column 66-67