4-BROMO-6-FLUORO (1H)INDAZOLE
- Product Name
- 4-BROMO-6-FLUORO (1H)INDAZOLE
- CAS No.
- 885520-70-7
- Chemical Name
- 4-BROMO-6-FLUORO (1H)INDAZOLE
- Synonyms
- 4-Bromo-6-fluoro-1H-indole;1H-INDOLE, 4-BROMO-6-FLUORO
- CBNumber
- CB32514830
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 885520-70-7.mol
4-BROMO-6-FLUORO (1H)INDAZOLE Property
- Boiling point:
- 315.1±22.0 °C(Predicted)
- Density
- 1.750
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 15.47±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid-Liquid Mixture
- InChI
- InChI=1S/C8H5BrFN/c9-7-3-5(10)4-8-6(7)1-2-11-8/h1-4,11H
- InChIKey
- DMOWKZSCECYXSE-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC(F)=C2)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B684400
- Product name
- 4-Bromo-6-fluoroindole
- Packaging
- 1g
- Price
- $1260
- Updated
- 2021/12/16
- Product number
- CS-W019334
- Product name
- 4-Bromo-6-fluoro-1H-indole
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB19167
- Product name
- 4-Bromo-6-fluoroindole
- Packaging
- 2g
- Price
- $600
- Updated
- 2021/12/16
- Product number
- FB19167
- Product name
- 4-Bromo-6-fluoroindole
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z5269
- Product name
- 4-Bromo-6-fluoro-1H-indole
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
4-BROMO-6-FLUORO (1H)INDAZOLE Chemical Properties,Usage,Production
Uses
Halogentated indole derivative used in the preparation of PI3 kinase inhibitors.
Uses
4-BROMO-6-FLUORO (1H)INDAZOLE used in the preparation of PI3 kinase inhibitors.
Synthesis
1093066-65-9
885520-70-7
1-Bromo-5-fluoro-2-methyl-3-nitrobenzene (7.49 g, 31.8 mmol) was used as a raw material, which was dissolved in dioxane (40 mL) and then DMF-DMA (21.0 mL, 158 mmol) and pyrrolidine (2.6 mL, 31.1 mmol) were added sequentially. The reaction mixture was heated at 100 °C for the reaction. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent to afford 1-[2-(2-bromo-4-fluoro-6-nitrophenyl)-1-methylethenyl]-pyrrolidine as a dark red residue (10.0 g, theoretical amount). This pyrrolidine derivative (10.0 g, 31.7 mmol) was mixed with Raney nickel (suspended in water, 15 mL) in MeOH:THF (1:1, 150 mL), and hydrazine monohydrate (2.3 mL, 47.4 mmol) was added slowly at 0 °C, followed by stirring the mixture for 5 h at room temperature. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc. The filtrates were combined and concentrated to dryness under reduced pressure to afford the title compound 4-bromo-6-fluoro-1H-indole as a light colored oil (2.57 g, 37% yield). NMR hydrogen spectrum (300 MHz, CDCl3) δH 6.57 (apparent triple peak, J = 2.7 Hz, 1H), 7.04 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.12 (double-double peak, J = 2.1, 9.1 Hz, 1H), 7.20-7.25 (multiple peaks, 1H), 8.25 (single peak, 1H).
References
[1] Patent: WO2008/152387, 2008, A1. Location in patent: Page/Page column 34
[2] Patent: WO2009/53716, 2009, A1. Location in patent: Page/Page column 56
[3] Patent: WO2008/152394, 2008, A1. Location in patent: Page/Page column 39
[4] Patent: WO2008/152390, 2008, A1. Location in patent: Page/Page column 54-55
4-BROMO-6-FLUORO (1H)INDAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-6-FLUORO (1H)INDAZOLE manufacturers
- Product
- 4-BROMO-6-FLUORO (1H)INDAZOLE 885520-70-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23