4-BROMO-7-FLUOROINDOLE

Product Name: 4-BROMO-7-FLUOROINDOLE
CAS No.: 883500-66-1
Chemical Name: 4-BROMO-7-FLUOROINDOLE
Synonyms: 4-BROMO-7-FLUOROINDOLE;1H-INDOLE,4-BROMO-7-FLUORO;4-BROMO-7-FLUORO-1H-INDOLE
CBNumber: CB8120829
Molecular Formula: C8H5BrFN
Formula Weight: 214.03
MOL File: 883500-66-1.mol

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4-BROMO-7-FLUOROINDOLE Property

Melting point:: 24-25℃
Boiling point:: 314.2±22.0 °C(Predicted)
Density: 1.750±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Sparingly Soluble (0.28 g/L) (25°C)
pka: 14.62±0.30(Predicted)
Appearance: Colorless to light yellow Liquid
Sensitive: Air Sensitive

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B804268
Product name: 4-bromo-7-fluoro-1H-indole
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB91764
Product name: 4-Bromo-7-fluoroindole
Packaging: 100mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 4100AC
Product name: 4-Bromo-7-fluoroindole
Packaging: 250mg
Price: $153
Updated: 2021/12/16

Apolloscientific

Product number: PC6872
Product name: 4-Bromo-7-fluoro-1H-indole
Packaging: 250mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB91764
Product name: 4-Bromo-7-fluoroindole
Packaging: 250mg
Price: $175
Updated: 2021/12/16

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4-BROMO-7-FLUOROINDOLE Chemical Properties,Usage,Production

Uses

It is a pharmaceutical intermediate.

Synthesis

364-73-8

1826-67-1

883500-66-1

Vinylmagnesium bromide (300 mL of a 1.0 M THF solution, 300 mmol) was slowly added dropwise to a solution of 4-bromo-1-fluoro-2-nitrobenzene (22 g, 100 mmol) in anhydrous THF (700 mL) at -40 °C. The reaction temperature was maintained at -40 °C and after 1 h, the reaction was quenched with saturated aqueous NH4Cl solution. Subsequently, the reaction mixture was extracted with EtOAc (ethyl acetate). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography, eluting with appropriate proportions of eluents to afford the target compound 4-bromo-7-fluoro-1H-indole (5 g, 23.3% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 6.56-6.58 (m, 1H), 6.72-6.79 (m, 1H), 7.06-7.17 (m, 1H), 7.20-7.24 (m, 1H), 8.45 (s, 1H).

References

[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: WO2013/117522, 2013, A1. Location in patent: Page/Page column 39
[3] Patent: US2015/18367, 2015, A1. Location in patent: Paragraph 0173; 0174
[4] Patent: EP2570125, 2013, A1. Location in patent: Paragraph 0151
[5] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 74

4-BROMO-7-FLUOROINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-7-FLUOROINDOLE Suppliers

China 86 India 2 Sweden 1 United Kingdom 3 United States 10 Global 102

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View Lastest Price from 4-BROMO-7-FLUOROINDOLE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Bromo-7-fluoro-1H-indole 883500-66-1
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Career Henan Chemical Co

Product: 4-BROMO-7-FLUOROINDOLE 883500-66-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-12-18

883500-66-1, 4-BROMO-7-FLUOROINDOLERelated Search:

4-BROMO-6-FLUORO (1H)INDAZOLE 4-BROMO-5-AZAINDOLE 1H-Indole, 4-broMo-5-Methoxy- NA 4-bromo-5-chloro indole 4-BROMO-7-METHYL-1H-INDOLE 1H-Indole, 4-broMo-5-Methyl- 6-Bromo-5-fluoroindole 4,4''-Diiodo-p-terphenyl 5-BROMO-3-FLUOROINDOLE 7-BROMO-5-FLUOROINDOLE 7-BROMO-4-FLUOROINDOLE 4-BROMO-7-FLUOROINDOLE 5-BROMO-7-FLUOROINDOLE 7-Bromo-6-fluoroindole 4-BROMO-6-FLUOROINDOLE 4-BROMO-7-FLUORO-1-METHYL-1H-INDOLE 4-BROMO-7-FLUORO-2-METHYL-1H-INDOLE

4-BROMO-7-FLUORO-1H-INDOLE

4-BROMO-7-FLUOROINDOLE

1H-INDOLE,4-BROMO-7-FLUORO

883500-66-1