ChemicalBook > CAS DataBase List > 4-BROMO-7-FLUOROINDOLE

4-BROMO-7-FLUOROINDOLE

Product Name
4-BROMO-7-FLUOROINDOLE
CAS No.
883500-66-1
Chemical Name
4-BROMO-7-FLUOROINDOLE
Synonyms
4-BROMO-7-FLUOROINDOLE;1H-INDOLE,4-BROMO-7-FLUORO;4-BROMO-7-FLUORO-1H-INDOLE
CBNumber
CB8120829
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
883500-66-1.mol
More
Less

4-BROMO-7-FLUOROINDOLE Property

Melting point:
24-25℃
Boiling point:
314.2±22.0 °C(Predicted)
Density 
1.750±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Sparingly Soluble (0.28 g/L) (25°C)
pka
14.62±0.30(Predicted)
Appearance
Colorless to light yellow Liquid
Sensitive 
Air Sensitive
More
Less

Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B804268
Product name
4-bromo-7-fluoro-1H-indole
Packaging
100mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB91764
Product name
4-Bromo-7-fluoroindole
Packaging
100mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
4100AC
Product name
4-Bromo-7-fluoroindole
Packaging
250mg
Price
$153
Updated
2021/12/16
Apolloscientific
Product number
PC6872
Product name
4-Bromo-7-fluoro-1H-indole
Packaging
250mg
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB91764
Product name
4-Bromo-7-fluoroindole
Packaging
250mg
Price
$175
Updated
2021/12/16
More
Less

4-BROMO-7-FLUOROINDOLE Chemical Properties,Usage,Production

Uses

It is a pharmaceutical intermediate.

Synthesis

364-73-8

1826-67-1

883500-66-1

Vinylmagnesium bromide (300 mL of a 1.0 M THF solution, 300 mmol) was slowly added dropwise to a solution of 4-bromo-1-fluoro-2-nitrobenzene (22 g, 100 mmol) in anhydrous THF (700 mL) at -40 °C. The reaction temperature was maintained at -40 °C and after 1 h, the reaction was quenched with saturated aqueous NH4Cl solution. Subsequently, the reaction mixture was extracted with EtOAc (ethyl acetate). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography, eluting with appropriate proportions of eluents to afford the target compound 4-bromo-7-fluoro-1H-indole (5 g, 23.3% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 6.56-6.58 (m, 1H), 6.72-6.79 (m, 1H), 7.06-7.17 (m, 1H), 7.20-7.24 (m, 1H), 8.45 (s, 1H).

References

[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: WO2013/117522, 2013, A1. Location in patent: Page/Page column 39
[3] Patent: US2015/18367, 2015, A1. Location in patent: Paragraph 0173; 0174
[4] Patent: EP2570125, 2013, A1. Location in patent: Paragraph 0151
[5] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 74

4-BROMO-7-FLUOROINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-BROMO-7-FLUOROINDOLE Suppliers

China 86 India 2 Sweden 1 United Kingdom 3 United States 10 Global 102
Clearsynth Labs Limited
Tel
+91-22-26355700
Fax
+91-22-26355701
Email
info@clearsynth.com
Country
India
ProdList
9679
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 4-BROMO-7-FLUOROINDOLE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-Bromo-7-fluoro-1H-indole 883500-66-1
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18
Career Henan Chemical Co
Product
4-BROMO-7-FLUOROINDOLE 883500-66-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-12-18

883500-66-1, 4-BROMO-7-FLUOROINDOLERelated Search:

4-BROMO-6-FLUORO (1H)INDAZOLE 4-BROMO-5-AZAINDOLE 1H-Indole, 4-broMo-5-Methoxy- NA 4-bromo-5-chloro indole 4-BROMO-7-METHYL-1H-INDOLE 1H-Indole, 4-broMo-5-Methyl- 6-Bromo-5-fluoroindole 4,4''-Diiodo-p-terphenyl 5-BROMO-3-FLUOROINDOLE 7-BROMO-5-FLUOROINDOLE 7-BROMO-4-FLUOROINDOLE 4-BROMO-7-FLUOROINDOLE 5-BROMO-7-FLUOROINDOLE 7-Bromo-6-fluoroindole 4-BROMO-6-FLUOROINDOLE 4-BROMO-7-FLUORO-1-METHYL-1H-INDOLE 4-BROMO-7-FLUORO-2-METHYL-1H-INDOLE

  • 4-BROMO-7-FLUORO-1H-INDOLE
  • 4-BROMO-7-FLUOROINDOLE
  • 1H-INDOLE,4-BROMO-7-FLUORO
  • 883500-66-1