ChemicalBook > CAS DataBase List > 4-BROMO-7-FLUOROINDOLE
4-BROMO-7-FLUOROINDOLE
- Product Name
- 4-BROMO-7-FLUOROINDOLE
- CAS No.
- 883500-66-1
- Chemical Name
- 4-BROMO-7-FLUOROINDOLE
- Synonyms
- 4-BROMO-7-FLUOROINDOLE;1H-INDOLE,4-BROMO-7-FLUORO;4-BROMO-7-FLUORO-1H-INDOLE
- CBNumber
- CB8120829
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 883500-66-1.mol
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4-BROMO-7-FLUOROINDOLE Property
- Melting point:
- 24-25℃
- Boiling point:
- 314.2±22.0 °C(Predicted)
- Density
- 1.750±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Sparingly Soluble (0.28 g/L) (25°C)
- pka
- 14.62±0.30(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Sensitive
- Air Sensitive
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Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- B804268
- Product name
- 4-bromo-7-fluoro-1H-indole
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB91764
- Product name
- 4-Bromo-7-fluoroindole
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
AK Scientific
- Product number
- 4100AC
- Product name
- 4-Bromo-7-fluoroindole
- Packaging
- 250mg
- Price
- $153
- Updated
- 2021/12/16
Apolloscientific
- Product number
- PC6872
- Product name
- 4-Bromo-7-fluoro-1H-indole
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB91764
- Product name
- 4-Bromo-7-fluoroindole
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
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4-BROMO-7-FLUOROINDOLE Chemical Properties,Usage,Production
Uses
It is a pharmaceutical intermediate.
Synthesis
364-73-8
1826-67-1
883500-66-1
Vinylmagnesium bromide (300 mL of a 1.0 M THF solution, 300 mmol) was slowly added dropwise to a solution of 4-bromo-1-fluoro-2-nitrobenzene (22 g, 100 mmol) in anhydrous THF (700 mL) at -40 °C. The reaction temperature was maintained at -40 °C and after 1 h, the reaction was quenched with saturated aqueous NH4Cl solution. Subsequently, the reaction mixture was extracted with EtOAc (ethyl acetate). The organic layers were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography, eluting with appropriate proportions of eluents to afford the target compound 4-bromo-7-fluoro-1H-indole (5 g, 23.3% yield). The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 6.56-6.58 (m, 1H), 6.72-6.79 (m, 1H), 7.06-7.17 (m, 1H), 7.20-7.24 (m, 1H), 8.45 (s, 1H).
References
[1] European Journal of Organic Chemistry, 2006, # 13, p. 2956 - 2969
[2] Patent: WO2013/117522, 2013, A1. Location in patent: Page/Page column 39
[3] Patent: US2015/18367, 2015, A1. Location in patent: Paragraph 0173; 0174
[4] Patent: EP2570125, 2013, A1. Location in patent: Paragraph 0151
[5] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 74
4-BROMO-7-FLUOROINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-7-FLUOROINDOLE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 4-Bromo-7-fluoro-1H-indole 883500-66-1
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99% min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
Career Henan Chemical Co
- Product
- 4-BROMO-7-FLUOROINDOLE 883500-66-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-12-18
883500-66-1, 4-BROMO-7-FLUOROINDOLERelated Search:
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1H-Indole, 4-broMo-5-Methoxy-
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4-BROMO-7-METHYL-1H-INDOLE
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5-BROMO-7-FLUOROINDOLE
7-Bromo-6-fluoroindole
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