ChemicalBook > CAS DataBase List > (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

Product Name
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
CAS No.
432531-71-0
Chemical Name
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
Synonyms
Necrosulfonami;MLKL Inhibitor;Necrosulfonamide(b);Necrosulfonamide HCl;(E/Z)-Necrosulfonamide;(E/Z)-Necrosulfonamide, 10 mM in DMSO;Necrosulfonamide, necroptosis inhibitor;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide
CBNumber
CB22620998
Molecular Formula
C18H15N5O6S2
Formula Weight
461.47
MOL File
432531-71-0.mol
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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Property

storage temp. 
+2C to +8C
solubility 
DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
form 
Dark yellow solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
480073
Product name
MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem<br />MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
Packaging
25mg
Price
$252
Updated
2025/07/31
TRC
Product number
N388600
Product name
Necrosulfonamide
Packaging
1mg
Price
$140
Updated
2021/12/16
TRC
Product number
N388600
Product name
Necrosulfonamide
Packaging
100mg
Price
$1390
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60598
Product name
Necrosulfonamide
Packaging
1mg
Price
$620
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60598
Product name
Necrosulfonamide
Packaging
10mg
Price
$750
Updated
2021/12/16
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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

Definition

ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.

Biological Activity

Cell permeable: yes', 'Primary Target
human MLKL', 'Reversible: no

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Suppliers

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432531-71-0, (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMideRelated Search:

Neomycin sulfate p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE

  • (E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
  • MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
  • (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
  • Necrosulfonami
  • N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide
  • Necrosulfonamide(b)
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  • (E/Z)-Necrosulfonamide
  • N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide
  • Necrosulfonamide HCl
  • Necrosulfonamide, necroptosis inhibitor
  • (E/Z)-Necrosulfonamide, 10 mM in DMSO
  • MLKL Inhibitor
  • 432531-71-0