(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

Product Name: (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
CAS No.: 432531-71-0
Chemical Name: (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
Synonyms: Necrosulfonami;Necrosulfonamide(b);Necrosulfonamide HCl;(E/Z)-Necrosulfonamide;Necrosulfonamide, necroptosis inhibitor;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide;(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide;(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
CBNumber: CB22620998
Molecular Formula: C18H15N5O6S2
Formula Weight: 461.47
MOL File: 432531-71-0.mol

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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Property

storage temp.: +2C to +8C
solubility: DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
form: Dark yellow solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 480073
Product name: MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem<br />MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
Packaging: 25mg
Price: $245
Updated: 2024/03/01

TRC

Product number: N388600
Product name: Necrosulfonamide
Packaging: 1mg
Price: $140
Updated: 2021/12/16

TRC

Product number: N388600
Product name: Necrosulfonamide
Packaging: 100mg
Price: $1390
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 60598
Product name: Necrosulfonamide
Packaging: 1mg
Price: $620
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 60598
Product name: Necrosulfonamide
Packaging: 10mg
Price: $750
Updated: 2021/12/16

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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

Definition

ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Suppliers

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432531-71-0, (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMideRelated Search:

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(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide

MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

Necrosulfonami

N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide

Necrosulfonamide(b)

2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-

(E/Z)-Necrosulfonamide

N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide

Necrosulfonamide HCl

Necrosulfonamide, necroptosis inhibitor

432531-71-0