(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
- Product Name
- (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
- CAS No.
- 432531-71-0
- Chemical Name
- (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
- Synonyms
- Necrosulfonami;Necrosulfonamide(b);Necrosulfonamide HCl;(E/Z)-Necrosulfonamide;Necrosulfonamide, necroptosis inhibitor;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;N-(4-(N-(3-methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophen-2-yl)acrylamide;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide;(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide;(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
- CBNumber
- CB22620998
- Molecular Formula
- C18H15N5O6S2
- Formula Weight
- 461.47
- MOL File
- 432531-71-0.mol
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Property
- storage temp.
- +2C to +8C
- solubility
- DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
- form
- Dark yellow solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 480073
- Product name
- MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem<br />MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
- Packaging
- 25mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- N388600
- Product name
- Necrosulfonamide
- Packaging
- 1mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- N388600
- Product name
- Necrosulfonamide
- Packaging
- 100mg
- Price
- $1390
- Updated
- 2021/12/16
- Product number
- 60598
- Product name
- Necrosulfonamide
- Packaging
- 1mg
- Price
- $620
- Updated
- 2021/12/16
- Product number
- 60598
- Product name
- Necrosulfonamide
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.
Definition
ChEBI: Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It is a sulfonamide, a member of pyrazines and a member of thiophenes.
(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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