2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-
- Product Name
- 2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-
- CAS No.
- 875787-07-8
- Chemical Name
- 2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-
- Synonyms
- CS-758;LXR623;WAY 252623;LXR623/LXR-623;LXR-623 (WAY-252623);LXR-623, 10 mM in DMSO;LXR-623 (WAY-252623) ，S8390;WAY-252623;LXR623;LXR 623;WAY252623;WAY 252623;2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)-;2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole
- CBNumber
- CB22626329
- Molecular Formula
- C21H12ClF5N2
- Formula Weight
- 422.78
- MOL File
- 875787-07-8.mol
2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Property
- Melting point:
- 93℃
- Boiling point:
- 528.4±50.0 °C(Predicted)
- Density
- 1.40
- storage temp.
- room temp
- solubility
- DMSO:50.0(Max Conc. mg/mL);118.26(Max Conc. mM)
Ethanol:52.0(Max Conc. mg/mL);123.0(Max Conc. mM) - pka
- -1.87±0.30(Predicted)
- form
- powder
- color
- white to beige
Safety
- RIDADR
- UN 2811 6.1 / PGIII
N-Bromosuccinimide Price
- Product number
- PZ0257
- Product name
- WAY-252623
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $118
- Updated
- 2024/03/01
- Product number
- PZ0257
- Product name
- WAY-252623
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $462
- Updated
- 2024/03/01
- Product number
- L0344
- Product name
- LXR-623
- Purity
- min. 97.0 %
- Packaging
- 10MG
- Price
- $181
- Updated
- 2025/07/31
- Product number
- L0344
- Product name
- LXR-623
- Purity
- min. 97.0 %
- Packaging
- 50MG
- Price
- $544
- Updated
- 2025/07/31
- Product number
- 21117
- Product name
- LXR-623
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Chemical Properties,Usage,Production
Uses
WAY 252623 is a novel and potent LXR (liverX receptor) β-agonist used as a potential candidate for the treatment of atopic dermatitis.
Biochem/physiol Actions
WAY-252623 (LXR623) is an orally available, potent and highly selective Liver X receptors (LXRs) agonist that significantly reduced total and LDL-cholesterol. WAY-252623 reduces lesion progression in the murine LDLR(-/-) atherosclerosis model.
in vivo
LXR-623 (400 mg/kg, p.o.) crosses the blood-brain barrier, induces target gene expression, and achieves therapeutic levels in GBM cells in the brain with minimal activity in the periphery. LXR-623 inhibits tumor growth, promotes tumor cell death, and prolongs the survival of mice bearing intracranial patient-derived GBMs[1]. LXR-623 (1.5, 5 mg/kg/day) significantly reduces progression of atherosclerosis in animals compared with the placebo group[2]. WAY-252623 (15 and 50 mg/kg) results in a significant reduction of atherosclerosis in a dose-dependent manner. WAY-252623 (20, 60, and 120 mg/kg/day, p.o.) displays neutral lipid effects in this CETP-expressing Syrian hamster[3]. Moreover, LXR-623 (50 mg/kg) induces gene expression in rodent peripheral blood cells in rat. LXR-623 (0, 15 and 50 mg/kg) dose-dependently upregulates transcription of ABCA1 and ABCG1 in monkey whole blood cells proportional to dose[4].
storage
Store at +4°C
2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
2H-Indazole, 2-[(2-chloro-4-fluorophenyl)Methyl]-3-(4-fluorophenyl)-7-(trifluoroMethyl)- Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58