AT-13148

Product Name: AT-13148
CAS No.: 1056901-62-2
Chemical Name: AT-13148
Synonyms: CS-1252;AT-13148;AT13148 HCl;AT13148, >=98%;AT-13148;AT 13148;AT-13148 USP/EP/BP;AT13148 hydrochloride;AT 13148 dihydrochloride;AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL;(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
CBNumber: CB22627346
Molecular Formula: C17H16ClN3O
Formula Weight: 313.78
MOL File: 1056901-62-2.mol

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AT-13148 Property

Boiling point:: 595.9±50.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 10.92±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 25mg
Price: $310
Updated: 2024/03/01

TRC

Product number: A790350
Product name: AT-13148
Packaging: 10mg
Price: $4150
Updated: 2021/12/16

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AT-13148 Chemical Properties,Usage,Production

Uses

AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor.

Biological Activity

at13148 is a novel, oral and atp-competitive inhibitor of multi-agc kinase with ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm for akt, p70s6 kinase, pka, sgk and rho kinase, respectively [1].

in vitro

studies, at13148 has been reported to inhibit activity of agc kinases which including akt, p70s6 kinase, pka, sgk and rho kinase with the ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm, respectively. in addition, at13148 has been revealed to inhibit proliferation with gi50 values of 1.54μm, 1.59μm, 1.82μm, 2.65μm and 3.77μm in mes-sa, bt474, hct-116, a549 and sk-ov-3 cell lines, respectively.

in vivo

studies, at13148 has shown the antitumor activity in multiple human tumor xenograft models including pten-deficient mes-sa human uterine sarcoma, her2-positive, pik3ca-mutant bt474 human breast cancer xenografts [1].

References

[1] yap ta1, walton mi, grimshaw km, te poele rh, eve pd, valenti mr, de haven brandon ak, martins v, zetterlund a, heaton sp, heinzmann k, jones ps, feltell re, reule m, woodhead sj, davies tg, lyons jf, raynaud fi, eccles sa, workman p, thompson nt, garrett md. at13148 is a novel, oral multi-agc kinase inhibitor with potent pharmacodynamic and antitumor activity. clin cancer res. 2012 jul 15;18(14):3912-23.

AT-13148 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-13148 Suppliers

China 68 The Netherlands 1 United Kingdom 1 United States 15 Global 85

Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 976
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Witofly Chemical Co.,Ltd

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Email: sales@witofly.com
Country: China
ProdList: 2864
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
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Suzhou yacoo science co.,Ltd

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Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
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AdooQ Bioscience CHINA

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Fax: 025-68650336
Email: info@adooq.cn
Country: China
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LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
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1056901-62-2, AT-13148Related Search:

Everolimus K 02288 SCH772984 L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) BEZ235 (NVP-BEZ235, Dactolisib)

AT-13148

(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol

AT13148 HCl

AT13148 hydrochloride

AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL

AT-13148;AT 13148

CS-1252

(alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol

(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol AT13148

AT13148, >=98%

AT 13148 dihydrochloride

(1S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol

Benzenemethanol, α-(aminomethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-, (αS)-

AT-13148 USP/EP/BP

inhibit,AT 13148,Protein kinase B,S6K,AT13148,PKB,AT-13148,ROK,Protein kinase A,Rho-associated protein kinase,Akt,PKA,Rho-associated kinase,Ribosomal S6 Kinase (RSK),Rho-kinase,ROCK,Inhibitor

1056901-62-2

Inhibitors