AT-13148

Product Name: AT-13148
CAS No.: 1056901-62-2
Chemical Name: AT-13148
Synonyms: CS-1252;AT-13148;AT13148 HCl;AT13148, >=98%;AT-13148;AT 13148;AT-13148 USP/EP/BP;AT13148 hydrochloride;AT13148, 10 mM in DMSO;AT 13148 dihydrochloride;AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL
CBNumber: CB22627346
Molecular Formula: C17H16ClN3O
Formula Weight: 313.78
MOL File: 1056901-62-2.mol

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AT-13148 Property

Boiling point:: 595.9±50.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 10.92±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 10mg
Price: $213
Updated: 2024/03/01

Cayman Chemical

Product number: 21597
Product name: AT-13148
Purity: ≥98%
Packaging: 25mg
Price: $310
Updated: 2024/03/01

TRC

Product number: A790350
Product name: AT-13148
Packaging: 10mg
Price: $4150
Updated: 2021/12/16

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AT-13148 Chemical Properties,Usage,Production

Uses

AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor.

Biological Activity

at13148 is a novel, oral and atp-competitive inhibitor of multi-agc kinase with ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm for akt, p70s6 kinase, pka, sgk and rho kinase, respectively [1].

in vitro

studies, at13148 has been reported to inhibit activity of agc kinases which including akt, p70s6 kinase, pka, sgk and rho kinase with the ic50 values of 38nm, 8nm, 3nm, 63nm and 4nm, respectively. in addition, at13148 has been revealed to inhibit proliferation with gi50 values of 1.54μm, 1.59μm, 1.82μm, 2.65μm and 3.77μm in mes-sa, bt474, hct-116, a549 and sk-ov-3 cell lines, respectively.

in vivo

studies, at13148 has shown the antitumor activity in multiple human tumor xenograft models including pten-deficient mes-sa human uterine sarcoma, her2-positive, pik3ca-mutant bt474 human breast cancer xenografts [1].

References

[1] yap ta1, walton mi, grimshaw km, te poele rh, eve pd, valenti mr, de haven brandon ak, martins v, zetterlund a, heaton sp, heinzmann k, jones ps, feltell re, reule m, woodhead sj, davies tg, lyons jf, raynaud fi, eccles sa, workman p, thompson nt, garrett md. at13148 is a novel, oral multi-agc kinase inhibitor with potent pharmacodynamic and antitumor activity. clin cancer res. 2012 jul 15;18(14):3912-23.

AT-13148 Preparation Products And Raw materials

Raw materials

Preparation Products

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AT-13148 Suppliers

China 74 The Netherlands 1 United Kingdom 1 United States 15 Global 91

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

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Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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ApexBio Technology

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Cayman Chemical Company

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ProdList: 6213
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United States Biological

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Combi-Blocks Inc.

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Axon Medchem LLC

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Matrix Scientific

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Selleck Chemicals LLC

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1056901-62-2, AT-13148Related Search:

Everolimus K 02288 SCH772984 L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoaMino]-, (Hydrochloride) (1:2) BEZ235 (NVP-BEZ235, Dactolisib)

AT-13148

(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol

AT13148 HCl

AT13148 hydrochloride

AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL

AT-13148;AT 13148

CS-1252

(alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol

(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol

(+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol AT13148

AT13148, >=98%

AT 13148 dihydrochloride

(1S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol

Benzenemethanol, α-(aminomethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-, (αS)-

AT-13148 USP/EP/BP

inhibit,AT 13148,Protein kinase B,S6K,AT13148,PKB,AT-13148,ROK,Protein kinase A,Rho-associated protein kinase,Akt,PKA,Rho-associated kinase,Ribosomal S6 Kinase (RSK),Rho-kinase,ROCK,Inhibitor

AT13148, 10 mM in DMSO

1056901-62-2

Inhibitors