ChemicalBook > CAS DataBase List > MTEP

MTEP

Product Name
MTEP
CAS No.
1186195-60-7
Chemical Name
MTEP
Synonyms
MTEP HCl;3-((2-Methyl-1;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
CBNumber
CB22628565
Molecular Formula
C11H9ClN2S
Formula Weight
236.72056
MOL File
1186195-60-7.mol
More
Less

MTEP Property

Melting point:
154-156℃ (isopropanol )
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
color 
Light cream
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
14961
Product name
MTEP (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$475
Updated
2024/03/01
TRC
Product number
M759900
Product name
MTEPHydrochloride
Packaging
1mg
Price
$50
Updated
2021/12/16
More
Less

MTEP Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.

Uses

MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.

in vitro

like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].

in vivo

mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].

IC 50

5 nm

storage

+4°C (desiccate)

References

[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.

MTEP Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MTEP Suppliers

Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
5004
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58

1186195-60-7, MTEPRelated Search:


  • 3-((2-Methyl-1
  • 3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP
  • 3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride
  • 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
  • 3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1)
  • MTEP HCl
  • Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride
  • 1186195-60-7