MTEP

Product Name: MTEP
CAS No.: 1186195-60-7
Chemical Name: MTEP
Synonyms: MTEP HCl;3-((2-Methyl-1;3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride;3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1);3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP;Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride;3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine
CBNumber: CB22628565
Molecular Formula: C11H9ClN2S
Formula Weight: 236.72056
MOL File: 1186195-60-7.mol

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MTEP Property

Melting point:: 154-156℃ (isopropanol )
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
color: Light cream

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14961
Product name: MTEP (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 14961
Product name: MTEP (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 14961
Product name: MTEP (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 14961
Product name: MTEP (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $475
Updated: 2024/03/01

TRC

Product number: M759900
Product name: MTEPHydrochloride
Packaging: 1mg
Price: $50
Updated: 2021/12/16

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MTEP Chemical Properties,Usage,Production

Description

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (K_i = 42 nM; IC₅₀ = 110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects.

Uses

MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.

in vitro

like mpep, mtep showed a nanomolar affinity for mglur5, but seemed to be superior to mpep in term of specificity. mtep did not influence mglur2, mglur7, nmda, ampa or kainate receptors, while inhibited maoa at a concentration three times higher than mpep. moreover, recent study indicated that mtep was five times stronger that mpep as an anxiolytic compound [1].

in vivo

mtep with doses between 0.5 and 3 mg/kg was found to decrease the haloperidol-induced muscle rigidity, which was measured as an increased muscle resistance of the rat hind leg. the longest and strongest effect was observed with the dose of 1 mg/kg. mtep was also found to reduce the haloperidol-induced increase in electromyographic activity recorded in the tibialis anterior and gastrocnemius muscles. 3 and 5 mg/kg of mtep could inhibit the haloperidol- induced catalepsy [1].

IC 50

5 nm

storage

+4°C (desiccate)

References

[1] ossowska k,konieczny j,wolfarth s,pilc a. mtep, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mglur5), produces antiparkinsonian-like effects in rats. neuropharmacology.2005 sep;49(4):447-55.

MTEP Preparation Products And Raw materials

Raw materials

Preparation Products

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MTEP Suppliers

China 22 United Kingdom 2 United States 10 Global 34

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2031
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3868
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3238
Advantage: 58

1186195-60-7, MTEPRelated Search:

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3-((2-METHYL-1;3-THIAZOL-4-YL)ETHYN-YL)PYRIDINE HYDROCHLORIDE;MTEP

3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine, 3-[(2-Methyl-4-thiazolyl)ethynyl]pyridine

3-[2-(2-Methyl-4-thiazolyl)ethynyl]pyridine hydrochloride (1:1)

MTEP HCl

Metabotropic glutamate receptors,mGluR,inhibit,Inhibitor,MTEP hydrochloride

1186195-60-7